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AML, Adult Recurrent clinical trials

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NCT ID: NCT06420063 Not yet recruiting - Clinical trials for Acute Myeloid Leukemia

Sequential CAR-T Cells Targeting CD33/CD123 in Patients With Acute Myelocytic Leukemia AML

BAH244
Start date: October 10, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

This is an open, single-arm, clinical study to evaluate the efficacy and safety of chimeric antigen receptor T cell immunotherapy (CAR-T) targeting CD33 or CD123 or both sequentially in the treatment of Acute Myelocytic Leukemia.

NCT ID: NCT05829226 Recruiting - MDS Clinical Trials

A Phase 1 Study With LYT-200 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML), or With Relapsed/Refractory, High-risk Myelodysplastic Syndrome (MDS)

Start date: December 12, 2022
Phase: Phase 1
Study type: Interventional

A Phase 1 Open-label, Multi-center Study of the Safety, Pharmacokinetics (PK), and Anti-tumor Activity of LYT- 200 in Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML), or with Relapsed/refractory, High-risk Myelodysplastic Syndrome (MDS)

NCT ID: NCT05758610 Recruiting - Clinical trials for AML, Adult Recurrent

A Phase I Study of Euthare-155008(ETH-155008) in AML and NHL Patients

Start date: November 4, 2022
Phase: Phase 1
Study type: Interventional

This Trial is an open-label, multicenter trial to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of ETH-155008 in subjects with AML and NHL who previously received standard treatment or are ineligible for standard treatment options.

NCT ID: NCT04901416 Recruiting - MDS Clinical Trials

Safety and Efficacy of Allogeneic NK Cell Infusions in Patients With Relapsed/Refractory AML and High Risk MDS

Start date: December 15, 2021
Phase: Phase 1
Study type: Interventional

This study involves the use of an investigational cell therapy known as DVX201. DVX201 is an investigational cell therapy that contains a type of white blood cell called natural killer (NK) cells. NK cells are a normal part of your immune system and have a lifespan of only about two weeks. They are called natural killer cells because they have the natural ability to identify and kill cells in the body that are abnormal, like cancer cells or virally infected cells. But fighting cancer can also lead to exhaustion and abnormal function of NK cells. It can also result in a significant decrease in the number of NK cells in the blood, making it more difficult for the immune system to control the disease. We believe that infusion of healthy, functional NK cells into patients with AML or MDS may boost the immune system and help by killing cancer cells that remain after chemotherapy. DVX201 is an investigational NK cell therapy that may provide a rapid and temporary source of healthy NK cells that are better able to fight those cancer cells.

NCT ID: NCT04678466 No longer available - Clinical trials for Acute Myeloid Leukemia

Flotetuzumab Expanded Access Program

Start date: n/a
Phase:
Study type: Expanded Access

The purpose of the Expanded Access program is to provide flotetuzumab to patients with acute myeloid leukemia (AML) for whom potential benefit justifies potential treatment risks.