The Effect of ProHydrolase® on the Amino Acid, Intramuscular Anabolic Signaling, and Endocrine Response to Resistance Exercise in Trained Males

Amino Acids Clinical Trial

Official title:

The Effect of ProHydrolase® on the Amino Acid, Intramuscular Anabolic Signaling, and Endocrine Response to Resistance Exercise in Trained Males

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04144114
• Other study ID #: Pro18
• Status: Completed
• Phase: N/A
• Start date: August 1, 2018
• Est. completion date: December 7, 2018

Study information

• Verified date: October 2019
• Source: Deerland Enzymes
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To examine the amino acid absorption following acute resistance exercise between three supplemental treatments: 1) Whey Protein + ProHydrolase (WPH) 2) Whey Protein (W) and 3) Non-Caloric Placebo (PL). To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on the mTORC1 complex pathway. To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on circulating concentrations of endocrine biomarkers.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: December 7, 2018
• Est. primary completion date: December 7, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• • At least one-year of resistance training experience

• Free of any physical limitations (determined by health and activity questionnaire).

• Between the ages of 18 and 35.

• Ability to leg press a weight equivalent to 1.5 times their body mass

Exclusion Criteria:

• • Inability to perform physical exercise (determined by health and activity questionnaire)

• Taking any other nutritional supplement or performance enhancing drug (determined from health and activity questionnaire).

• Physical injury preventing the athlete from participating in offseason training

• Any chronic illness that causes continuous medical care

Related Conditions & MeSH terms

• Amino Acids

Intervention

Dietary Supplement:
• ProHydrolase®
Subjects received 250mg of ProHydrolase® with 25g whey protein mixed together in a drink
• Whey protein
Subjects received 25g of whey protein powder mixed to together in a drink
• Placebo
Placebo

Locations

Country	Name	City	State
United States	Lipscomb University	Nashville	Tennessee

Sponsors (2)

Lead Sponsor	Collaborator
Deerland Enzymes	Lipscomb University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Amino acid absorption	To examine the amino acid absorption following acute resistance exercise between three supplemental treatments: 1) Whey Protein + ProHydrolase (WPH) 2) Whey Protein (W) and 3) Non-Caloric Placebo (PL)	4 weeks
Primary	mTORC1 pathway	To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on the mTORC1 complex pathway	4 weeks
Primary	Endocrine markers	To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on circulating concentrations of endocrine biomarkers.	4 weeks