Clinical Trial Details
— Status: Recruiting
Administrative data
| NCT number |
NCT05343247 |
| Other study ID # |
2021/76 |
| Secondary ID |
|
| Status |
Recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
March 1, 2022 |
| Est. completion date |
May 15, 2024 |
Study information
| Verified date |
November 2023 |
| Source |
Istanbul University |
| Contact |
Yelda Kasimoglu Eldem, Assoc. Prof. |
| Phone |
00905336233978 |
| Email |
yelda.kasimoglu[@]istanbul.edu.tr |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
The aim of this study is to investigate whether there is a significant difference in dental
age between children with amelogenesis imperfecta (AI) and healthy controls using Willems
method, Cameriere European formula and London Atlas. If there is a significant difference in
dental age between children with AI and healthy controls, it is aimed to create a new
formula.
Description:
One of the developmental enamel defects, amelogenesis imperfecta (AI), is also known as
enamel hypoplasia/hypomineralization. It is a rare inherited disease that affects the enamel
structure, amount and component in primary and permanent teeth, and it has been reported to
be accompanied by some dental anomalies and nephrocalcinosis. Dental anomalies and
nephrocalcinosis can affect tooth development, and there are limited studies examining tooth
development in these individuals.Dental age is widely evaluated by pedodontists, forensic
dentists and orthodontists. While a delay in tooth development may be associated with growth
retardation and learning difficulties, dental age determination can also be used for forensic
age determination for children whose birth information is uncertain. A clear assessment of
maturation in children with continued growth is important in establishing a dental treatment
plan.
Dental age is widely evaluated by pedodontists, forensic dentists and orthodontists. While a
delay in tooth development may be associated with growth retardation and learning
difficulties, dental age determination can also be used for forensic age determination for
children whose birth information is uncertain. A clear assessment of maturation in children
with continued growth is important in establishing a dental treatment plan.
There are two basic approaches to dental age determination in children:
1. evaluation of eruption of teeth in the oral cavity,
2. evaluation of the development and mineralization of crowns and roots on dental
radiographs.
In many methods, the developmental stages of different numbers of permanent teeth are used.
The most commonly used method for determining dental age in children; is the Demirjian method
that evaluates the development of seven left permanent mandibular teeth in eight stages (from
A to H). Willems et al. In 2001, they modified the Demirjian method by conducting a study on
the fact that it showed higher age determination in the Belgian Caucasian population. The
adapted method was named the Willems method. It is stated that one of the advantages of this
method is that it is a relatively simple system for determining tooth age.
One of the most widely used methods of dental age determination recently is the European
formula of Cameriere et al., which is calculated based on open apex. It has been reported
that this method has been tested on different population groups, and the results are accurate
and reliable.
An atlas method was proposed by a group of London researchers in 2010. The Atlas shows all
the teeth array images of certain age groups as a schematic series. Age determination is made
by deciding which reference image matches the individual's panoramic radiography image more.
