Amelogenesis Imperfecta Clinical Trial
— COLOEMAILOfficial title:
Colorimetric Comparison of Email Defects Using Spectrophotometric and Computer Techniques and Biological, Structural and Physico-chemical Analyses of Teeth or Pathological Enamel
The study focuses on the analysis of enamel defects grouping together hypomineralization and hypoplasia. It focuses on 3 very characteristic enamel pathologies that are most often encountered in dental consultations: Molar Incisor Hypomineralization (MIH), dental fluorosis (FD) and amelogenesis imperfecta (AI). The research focuses on the use of a spectrophotometer for measuring tooth colors: the Zfx SpectroShade® (MHT) and its software as a means of early diagnosis of pre-eruptive enamel abnormalities. The main objective of the study is to analyze the color parameters of teeth affected with one of the 3 enamel abnormalities for use of the spectrophotometer as a non-invasive diagnostic tool for enamel defects. The secondary objective is focused on the biological, structural and physicochemical characterizations of these different enamel pathologies from extracted teeth or enamel biopsies that must be ground to achieve a restoration.
Status | Recruiting |
Enrollment | 80 |
Est. completion date | September 18, 2024 |
Est. primary completion date | July 18, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 8 Years to 55 Years |
Eligibility | For patients : Inclusion Criteria : 1. Age between 8 and 55 years old 2. Carrier of one of the following 3 quantitative pre-eruptive enamel anomalies : AIH, dental fluorosis or MIH 3. Information and collection of the non-opposition of the adult patient or of the representative(s) of parental authority present for the minors. Criteria for non-inclusion : 1. Pregnant or breastfeeding woman 2. Under guardianship or curators 3. Opposition of the minor patient 4. Presenting pre-eruptive anomalies only on the molars (the spectrophotometer can only take pictures of the anterior dental sector (incisors and canines)). 5. Other types of hypomineralization (post-eruptive, of traumatic or infectious origin, idiopathic). 6. Having undergone radiotherapy or chemotherapy inducing dental and periodontal damage. 7. Having systemic abnormalities (unbalanced diseases), haemochromatosis, porphyria 8. Under medication likely to disturb the coloring of the teeth For witnesses : Inclusion Criteria : 1. Age between 8 and 55 years old 2. Information and collection of the non-opposition of the adult witness or of the representative(s) of parental authority present for the minors. 3. Free of any anomaly of tooth structure, exogenous dyschromia and carious lesions. Criteria for non-inclusion : 1. Pregnant or breastfeeding woman 2. Under guardianship or curators 3. Opposition of the minor witness 4. Carrier of a quantitative pre-eruptive enamel anomaly 5. Polycarpus (preventing the diagnosis of amyl hypomineralization) |
Country | Name | City | State |
---|---|---|---|
France | Service d'odontologie, Hôpital Pitié-Salpêtrière | Paris |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | analyze the color parameters of teeth presenting one of the 3 enamel anomalies in order to use the spectrophotometer as a non-invasive diagnostic tool for enamel dyschromia. | at the first visit = inclusion visit | ||
Secondary | Biological characterization of the proteins of the dental enamel matrix by Western Blot and/or mass spectrometry from samples (extracted teeth or enamel biopsies to be ground during the treatment). | at the second visit, 2 months after inclusion visit and after tooth extraction | ||
Secondary | Ultra-structural characterization under electron microscope and biomechanics by nanoindentation of enamel pathologies from extracted teeth or enamel biopsies to be ground during the treatment. | at the second visit, 2 months after inclusion visit and after tooth extraction | ||
Secondary | Physico-chemical characterization by different spectroscopic techniques of enamel pathologies from extracted teeth or enamel biopsies to be ground during the treatment. | at the second visit, 2 months after inclusion visit and after tooth extraction | ||
Secondary | Physico-chemical characterization by atomic probe tomography of enamel pathologies from extracted teeth or enamel biopsies to be ground during the treatment. | at the second visit, 2 months after inclusion visit and after tooth extraction |
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