CNV in AMD Analyzed by OCT Angiography Under IntravitreaL Eylea (COCTAEyl)

AMD Clinical Trial

— COCTAEyl  

Official title:

CNV in AMD Analyzed by OCT Angiography Under IntravitreaL Eylea (COCTAEyl)

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03803631
• Other study ID #: COCTAEyl
• Status: Active, not recruiting
• Start date: April 4, 2018
• Est. completion date: July 31, 2023

Study information

• Verified date: June 2023
• Source: Centre Hospitalier Intercommunal Creteil
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The main objective of this study is to analyze a new noninvasive imaging examination, OCT angiography, in the evaluation of neovascular remodeling and early signs of recurrence of wet AMD undergoing treatment on OCTA and to correlate OCTA findings with SD-OCT findings.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 49
• Est. completion date: July 31, 2023
• Est. primary completion date: January 15, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 55 Years and older

Eligibility

Inclusion Criteria:

• Naïve patients
• Type 1 or type 2 Choroidal NeoVascularization (CNV)
• Age = 55 years
• Presence of subfoveal CNV secondary to Age-related Macular Degeneration (AMD)
• At the time of inclusion, multimodal imaging should reveal exudative features
• Exudative AMD diagnosis established between 1 and 7 days before inclusion
• Monitored monthly
• Loading phase then bimonthly retreatment.
• Signed Informed Consent.
• Patient covered by the French Health Insurance

Exclusion Criteria:

• Polypoidal choroidal vasculopathy
• Type 3 neovascularization
• Choroidal neovascularization attributable to causes other than AMD
• Macular hematoma
• Pigment epithelial detachment higher than 150µm
• Fibrosis > 50% lesion on fundus color photography, fibroglial scar
• Media opacity annoying acquisition
• Retinal vascular occlusion
• Diabetic retinopathy
• Adult-onset foveomacular vitelliform dystrophy and other pattern dystrophies,
• Refractive error >-6D
• Active intraocular inflammation in the study eye
• Patient who does not meet the local indication criteria for Eylea® treatment. Contraindications listed in the SmPCs must be taken into account
• Patient taking part in an interventional study at the time of enrolment.
• Any history of allergy to the antiseptic used during preparation of the eye for the IVT injection in the investigational site (e.g. povidone iodine or chlorhexidine).
• Pregnant and lactating women
• Stroke and/or myocardial infarction 3 months before inclusion

Related Conditions & MeSH terms

• AMD
• Exudative Macular Degeneration
• Macular Degeneration
• Wet Macular Degeneration

Locations

Country	Name	City	State
France	Hôpital Pellegrin, CHU de Bordeaux	Bordeaux
France	CHI de Créteil	Créteil
France	Hôpital La Croix Rousse	Lyon
France	Centre Ophtalmologique d'Imagerie et de Laser,	Paris
France	Hôpital Lariboisière, APHP	Paris

Sponsors (2)

Lead Sponsor	Collaborator
Centre Hospitalier Intercommunal Creteil	Bayer

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 13
Primary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 13
Primary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 13
Primary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 13
Primary	presence of vascular loops on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 13
Primary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 13
Primary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 13
Primary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 13
Primary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 13
Primary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 13
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	baseline
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 1
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 2
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 3
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 4
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 5
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 6
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 7
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 8
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 9
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 10
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 11
Secondary	presence of flow on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 12
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	baseline
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month1
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 2
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 3
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 4
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 5
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 6
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 7
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 8
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 9
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 10
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 11
Secondary	presence of collaterals on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 12
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	baseline
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 1
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 2
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 3
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 4
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 5
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 6
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 7
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 8
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 9
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 10
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 11
Secondary	presence of peripheral arcade on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 12
Secondary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 1
Secondary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 2
Secondary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 3
Secondary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 4
Secondary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 5
Secondary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 6
Secondary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 7
Secondary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 8
Secondary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 9
Secondary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 10
Secondary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 11
Secondary	presence of arteriolization on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 12
Secondary	presence of vascular loops on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	baseline
Secondary	presence of vascular loops on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 1
Secondary	presence of vascular loops on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 2
Secondary	presence of vascular loops on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 3
Secondary	presence of vascular loops on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 4
Secondary	presence of vascular loops on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 5
Secondary	presence of vascular loops on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 6
Secondary	presence of vascular loops on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 7
Secondary	presence of vascular loops on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 8
Secondary	presence of vascular loops on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 9
Secondary	presence of vascular loops on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 10
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	baseline
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 1
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 2
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 3
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 4
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 5
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 6
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 7
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 8
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 9
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 10
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 11
Secondary	presence of dark halo on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 12
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	baseline
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 1
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 2
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 3
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 4
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 5
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 6
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 7
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 8
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 9
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 10
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 11
Secondary	presence of feeder vessel on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 12
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	baseline
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 1
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 2
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 3
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 4
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 5
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 6
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 7
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 8
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 9
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 10
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 11
Secondary	presence of flow void on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 12
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	baseline
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 1
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 2
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 3
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 4
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 5
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 6
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 7
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 8
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 9
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 10
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 11
Secondary	measure of neovascular area on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 12
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	baseline
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 1
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 2
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 3
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 4
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 5
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 6
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 7
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 8
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 9
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 10
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 11
Secondary	measure of neovascular density on OCTA	high flow on OCTA corresponding to the neovascular network with vascular remodeling over time	at month 12
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 13
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at baseline
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 1
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 2
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 3
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 4
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 5
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 6
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 7
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 8
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 9
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 10
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 11
Secondary	Intraretinal and/or subretinal fluid in SD-OCT		at month 12
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at baseline
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 1
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 2
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 3
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 4
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 5
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 6
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 7
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 8
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 9
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 10
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 11
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 12
Secondary	visual acuity in logmar	Measure of best-corrected visual acuity (BCVA) measured on ETDRS	at month 13
Secondary	presence or abscence of hemorrhage, fibrosis and atrophy on fundus color photography		at 1 months
Secondary	presence or abscence of hemorrhage on fundus color photography		at 1 months
Secondary	presence or abscence of fibrosis on fundus color photography		at 1 months
Secondary	presence or abscence of atrophy on fundus color photography		at 1 months
Secondary	presence or abscence of hemorrhage on fundus color photography		at 13 months
Secondary	presence or abscence of fibrosis on fundus color photography		at 13 months
Secondary	presence or abscence of atrophy on fundus color photography		at 13 months
Secondary	type of choroidal neovascularization on fluorescein angiography (type 1, type 2 or mixed lesions)		Baseline
Secondary	type of choroidal neovascularization on fluorescein angiography (type 1, type 2 or mixed lesions)		at month 13
Secondary	type of choroidal neovascularization on indocyanine green angiography (type 1, type 2 or mixed lesions)		baseline
Secondary	type of choroidal neovascularization on indocyanine green angiography (type 1, type 2 or mixed lesions)		at month 13
Secondary	choroidal thickness on EDI-OCT		monthly during 13 months
Secondary	type of choroidal neovascularization on SD-OCT (type 1, type 2 or mixed lesions)		monthly during 13 months