Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 13 |
|
Primary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 13 |
|
Primary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 13 |
|
Primary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 13 |
|
Primary |
presence of vascular loops on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 13 |
|
Primary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 13 |
|
Primary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 13 |
|
Primary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 13 |
|
Primary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 13 |
|
Primary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 13 |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
baseline |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 1 |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 2 |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 3 |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 4 |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 5 |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 6 |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 7 |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 8 |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 9 |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 10 |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 11 |
|
Secondary |
presence of flow on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 12 |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
baseline |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month1 |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 2 |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 3 |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 4 |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 5 |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 6 |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 7 |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 8 |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 9 |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 10 |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 11 |
|
Secondary |
presence of collaterals on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 12 |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
baseline |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 1 |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 2 |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 3 |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 4 |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 5 |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 6 |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 7 |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 8 |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 9 |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 10 |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 11 |
|
Secondary |
presence of peripheral arcade on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 12 |
|
Secondary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 1 |
|
Secondary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 2 |
|
Secondary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 3 |
|
Secondary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 4 |
|
Secondary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 5 |
|
Secondary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 6 |
|
Secondary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 7 |
|
Secondary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 8 |
|
Secondary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 9 |
|
Secondary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 10 |
|
Secondary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 11 |
|
Secondary |
presence of arteriolization on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 12 |
|
Secondary |
presence of vascular loops on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
baseline |
|
Secondary |
presence of vascular loops on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 1 |
|
Secondary |
presence of vascular loops on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 2 |
|
Secondary |
presence of vascular loops on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 3 |
|
Secondary |
presence of vascular loops on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 4 |
|
Secondary |
presence of vascular loops on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 5 |
|
Secondary |
presence of vascular loops on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 6 |
|
Secondary |
presence of vascular loops on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 7 |
|
Secondary |
presence of vascular loops on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 8 |
|
Secondary |
presence of vascular loops on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 9 |
|
Secondary |
presence of vascular loops on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 10 |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
baseline |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 1 |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 2 |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 3 |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 4 |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 5 |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 6 |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 7 |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 8 |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 9 |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 10 |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 11 |
|
Secondary |
presence of dark halo on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 12 |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
baseline |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 1 |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 2 |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 3 |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 4 |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 5 |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 6 |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 7 |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 8 |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 9 |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 10 |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 11 |
|
Secondary |
presence of feeder vessel on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 12 |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
baseline |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 1 |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 2 |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 3 |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 4 |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 5 |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 6 |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 7 |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 8 |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 9 |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 10 |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 11 |
|
Secondary |
presence of flow void on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 12 |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
baseline |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 1 |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 2 |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 3 |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 4 |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 5 |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 6 |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 7 |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 8 |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 9 |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 10 |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 11 |
|
Secondary |
measure of neovascular area on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 12 |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
baseline |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 1 |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 2 |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 3 |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 4 |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 5 |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 6 |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 7 |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 8 |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 9 |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 10 |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 11 |
|
Secondary |
measure of neovascular density on OCTA |
high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
at month 12 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 13 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at baseline |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 1 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 2 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 3 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 4 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 5 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 6 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 7 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 8 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 9 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 10 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 11 |
|
Secondary |
Intraretinal and/or subretinal fluid in SD-OCT |
|
at month 12 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at baseline |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 1 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 2 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 3 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 4 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 5 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 6 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 7 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 8 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 9 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 10 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 11 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 12 |
|
Secondary |
visual acuity in logmar |
Measure of best-corrected visual acuity (BCVA) measured on ETDRS |
at month 13 |
|
Secondary |
presence or abscence of hemorrhage, fibrosis and atrophy on fundus color photography |
|
at 1 months |
|
Secondary |
presence or abscence of hemorrhage on fundus color photography |
|
at 1 months |
|
Secondary |
presence or abscence of fibrosis on fundus color photography |
|
at 1 months |
|
Secondary |
presence or abscence of atrophy on fundus color photography |
|
at 1 months |
|
Secondary |
presence or abscence of hemorrhage on fundus color photography |
|
at 13 months |
|
Secondary |
presence or abscence of fibrosis on fundus color photography |
|
at 13 months |
|
Secondary |
presence or abscence of atrophy on fundus color photography |
|
at 13 months |
|
Secondary |
type of choroidal neovascularization on fluorescein angiography (type 1, type 2 or mixed lesions) |
|
Baseline |
|
Secondary |
type of choroidal neovascularization on fluorescein angiography (type 1, type 2 or mixed lesions) |
|
at month 13 |
|
Secondary |
type of choroidal neovascularization on indocyanine green angiography (type 1, type 2 or mixed lesions) |
|
baseline |
|
Secondary |
type of choroidal neovascularization on indocyanine green angiography (type 1, type 2 or mixed lesions) |
|
at month 13 |
|
Secondary |
choroidal thickness on EDI-OCT |
|
monthly during 13 months |
|
Secondary |
type of choroidal neovascularization on SD-OCT (type 1, type 2 or mixed lesions) |
|
monthly during 13 months |
|