Amblyopia Clinical Trial
Official title:
Will Perceptual Learning Via Video Game Playing Improve Visual Acuity, Stereopsis and Fixation Stability in Mild Amblyopes? Part 2 Study
Contrast balanced dichoptic videogame training has been found to improve sensory functions in adults with amblyopia; best corrected distance visual acuity (BCVA) and stereopsis, but its effect on motor function, namely amblyopic eye fixation stability, is unknown. Furthermore, the effect of treatment in cases of mild amblyopia is not well understood. The aim of this study is to find out the difference on fixation stability, BCVA and stereopsis in mild amblyopes after 6 weeks' contrast balanced dichoptic video game training.
Objectives: To assess the change of fixation stability as well as visual acuity and
stereopsis before and after training mild amblyopia by perceptual learning through dichoptic
video game playing.
Hypothesis: It has been shown that the visual acuity, stereopsis and fixation stability are
compromised in amblyopic eye. Perceptual learning via video game playing has been found
effective in improving visual acuity and stereoacuity in moderate and severe amblyopic eyes,
but there is no study on such treatment in mild amblyopia. In this study, we hypothesize that
fixation stability, visual acuity and stereopsis will be improved after training by dichoptic
video game playing in mild amblyopia.
Methods: Participants (aged 7 or above) with Best Corrected Visual Acuity (BCVA) ≤ 0.28
logMAR in the amblyopic eye and an interocular acuity difference ≥ 0.2 logMAR will be
recruited. An anaglyphic, contrast balanced dichoptic video game will be provided on an i-Pod
Touch (Apple Inc.) for 6 weeks of home-based training (60 mins per day). Fixation stability
quantified using bivariate contour ellipse area (BCEA by micro-perimeter (MP) Nidek MP-1),
BCVA and stereopsis will be assessed before and after treatment.
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