Alzheimer's Disease Clinical Trial
Official title:
Magnetic Resonance Imaging to Measure Treatment Effects of Doxycycline and Rifampicin in Alzheimer's Disease
Objectives:
To study the changes in brain structure and function using MRI scans in patients treated for
Alzheimer's disease.
Methods:
A pilot study of treating Alzheimer's disease with antibiotics showed some promise that this
treatment could delay the deterioration of the mind with this disease. This study is being
replicated on a larger scale, providing a more definitive answer to this question. In
addition to looking at changes of the mind (through cognitive tests), we would like to use
MRI scans in these patients before and after treatment to study the structural changes and
the chemical changes in the brain. This would provide a non-invasive look at the bran
processes that protect the brain from the effect of Alzheimer's as well as confirming that
the disease has been modified with treatment.
Impact:
The novel treatment of Alzheimer's with antibiotics has provided a potential breakthrough in
the field. In addition to verifying changes in the brain, MRI scans can observe HOW this
process could occur, thus opening doors to other new treatments for Alzheimer's and perhaps
even cures.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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