Alzheimer's Disease Clinical Trial
Official title:
Biochemical and Genetic Studies in Familial Alzheimer's Disease
Alzheimer's disease is a condition marked by the deterioration of mental function. The
disease usually begins in late middle life and results in death in 5 to 10 years. Patients
with Alzheimer's disease typically suffer from memory loss, confusion, and disorientation.
The condition has become a major medical and social problem in the United States because of
the increasing number of people living beyond the age of 65. The actual cause of Alzheimer's
disease is unknown.
Researchers believe that Alzheimer's disease, or at least a portion of cases, may be an
inherited condition. As a result, many new techniques have been developed to study the
genetic causes of Alzheimer's disease and other neurological disorders. Many of these
genetic techniques require blood samples and a family pedigree. A pedigree is a chart,
similar to a family tree, that shows a patient's family history.
The purpose of this study is to collect family and psychosocial information, blood, and
biopsy samples from patients with neurological diseases, their families, and normal
volunteers. This information gathered will be used to learn more about diseases that affect
the brain.
Status | Completed |
Enrollment | 1500 |
Est. completion date | February 2004 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
INCLUSION/EXCLUSION CRITERIA Need to know extensive family history information. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Nee LE, Polinsky RJ, Eldridge R, Weingartner H, Smallberg S, Ebert M. A family with histologically confirmed Alzheimer's disease. Arch Neurol. 1983 Apr;40(4):203-8. — View Citation
Nee LE. Effects of psychosocial interactions at a cellular level. Soc Work. 1995 Mar;40(2):259-62. Review. — View Citation
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 1995 Jun 29;375(6534):754-60. — View Citation
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