Design of Personalised supplemenTs Based on the Gut micRobiota Through Artificial Intelligence for Alzheimer's Patients — TREAT  

Alzheimer Disease Clinical Trial

Official title: Design of Personalised supplemenTs Based on the Gut micRobiota of Alzheimer Patients Through Network and Artificial Intelligence Analysis

Status Recruiting

Clinical Trial Summary

Studies indicate that the intestinal microbiota could have an implication in Alzheimer's disease; recently, a positive relationship has been established between levels of bacterial lipopolysaccharide (LPS) and cerebral amyloidosis and a negative relationship between the production of the chain fatty acid cuts butyrate by the intestinal microbiota and cerebral amyloidosis. Currently there is no effective treatment for Alzheimer's, but studies indicate that a healthy diet such as the Mediterranean diet and physical exercise delay the symptoms of this disease. For all these reasons, it is postulated that introducing changes in the intestinal microbiota through diet may be a new treatment or serve as an adjuvant treatment for Alzheimer's disease.

Clinical Trial Description

The study consists of three main stages, a first part in which healthy subjects and patients will be characterized. With all the variables obtained, network analyzes and predictive analyzes are carried out in order to see the interaction between variables and determine predictive variables of Alzheimer's disease that could be subject to modification by the diet. In a second stage, the personalized supplement will be designed based on the characteristics of Alzheimer's patients and there is no patient participation. In a third stage, a randomized, parallel nutritional intervention trial will be carried out where the supplement designed "ad hoc" will be compared in the population of Alzheimer's patients against a nutritional supplement commonly used in Alzheimer's patients. ;

Related Conditions & MeSH terms

• Alzheimer Disease
• Gut Microbiota

• NCT number: NCT06199193
• Study type: Interventional
• Source: Universidad Complutense de Madrid
• Contact: Mar Larrosa, PhD
• Phone: +34913942041
• Email: mlarrosa@ucm.es
• Status: Recruiting
• Phase: N/A
• Start date: February 1, 2024
• Completion date: December 31, 2025