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A Study to Assess Safety and Target Engagement of E2814 in Participants With Mild to Moderate Cognitive Impairment Due to Dominantly Inherited Alzheimer's Disease

Alzheimer Disease Clinical Trial

Official title:
An Open-Label Phase 1b/2 Study to Assess Safety and Target Engagement of E2814 in Subjects With Mild to Moderate Cognitive Impairment Due to Dominantly Inherited Alzheimer's Disease

Clinical Trial Summary

The primary objective of the study is to assess the safety and tolerability of intravenous (IV) infusions of E2814 in participants with dominantly inherited Alzheimer's disease (DIAD), and to evaluate target engagement (TE) of E2814 on microtubule binding region (MTBR)-tau species in cerebrospinal fluid (CSF) in participants with DIAD.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04971733
Study type Interventional
Source Eisai Inc.
Contact Eisai Medical Information
Phone +1-888-274-2378
Email esi_medinfo@eisai.com
Status Recruiting
Phase Phase 1/Phase 2
Start date June 28, 2021
Completion date July 14, 2025
View Details
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