Alzheimer Disease Clinical Trial
Official title:
Effects of Mixed Functional Foods Supplementation on Cognition and Neuroimaging Biomarkers in Adults With Subject Cognitive Decline
Alzheimer's disease (AD) is the most common form of neurodegenerative disorders leading to dementia. Currently, there has been no effective drugs targeting this disease. Functional food is considered as a potentially non-pharmacologic treatment. In this project, the investigators aim to investigate the effectiveness of a mixed functional food with main compositions of ginsenoside, green tea polyphenols and marine collagen peptide on cognition for individuals with subjective cognitive decline (SCD). Taking the randomized, double-blind, placebo-controlled method, participants in the functional food group will take mixed functional foods for three months and those in the placebo group will take placebo. After that, the investigators will investigate the changes of cognitive function. Furthermore, based on the neuroimaging technique, the regulatory mechanism of functional food in intervening SCD will be revealed from the perspective of altered brain functional activity. In conclusion, these results are beneficial for understanding the therapeutic effect of mixed functional foods as a non-drug treatment for early AD and further elucidating the potential brain mechanism, which are of great values in solving scientific and clinical practice issues.
Currently, there has been no effective therapy for Alzheimer's disease (AD). Functional food
is now considered as a potentially non-pharmacologic intervention and supplementation of
functional food may positively affect cognitive function for patients with AD. However, there
are few existing studies involving the role of mixed functional foods with multiple
compositions on cognition and neuroimaging biomarkers for subjective cognitive decline (SCD).
Sixty participants with SCD will be recruited in this three-month, randomized, double-blind,
placebo-controlled trial. Each group had thirty participants. Participants in the functional
food group will take mixed functional foods for three months and those in the placebo group
will take placebo. After that, the investigators will investigate the changes of memory
measures, which is the primary outcome. Furthermore, based on the neuroimaging technique of
functional near-infrared spectroscopy (fNIRS), the regulatory mechanism of mixed functional
foods in intervening SCD will be revealed from the perspective of altered brain functional
activity.
In conclusion, these results are beneficial for understanding the therapeutic effect of mixed
functional foods as a non-drug therapy for preclinical AD and further elucidating the
potential brain mechanism, which are of great values in solving scientific and clinical
practice issues.
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