Retinal Nerve Fiber Layer Thickness and Cerebrospinal Fluid Aβ/Tau

Alzheimer Disease Clinical Trial

Official title: Association of Retinal Nerve Fiber Layer (RNFL) Thickness With Cerebrospinal Fluid Aβ and Tau Concentration

Status Completed

Clinical Trial Summary

To test the hypothesis that retinal nerve fiber layer (RNFL) thickness is correlated with Aβ and Tau concentration of cerebrospinal fluid (CSF) in an older population.

Clinical Trial Description

retinal nerve fiber layer (RNFL) thickness changing has been reported in Alzheimer's Disease (AD) patients at an early stage, and has been demonstrated as a potential biomarker able to predict cognitive deterioration (Hinton DR et al., N Engl J Med 1986; London A et al. Nat Rev Neurol 2013; Chang LY et al., Alzheimers Dement 2014). However, whether RNFL thickness is correlated with cerebrospinal fluid (CSF) features of AD pathogenesis (e.g., Aβ and Tau) remains unclear. The investigators thus conducted this observational cohort study to test the correlation between RNFL thickness changing and CSF, to further validate RNFL as a potential AD biomarker. ;

Related Conditions & MeSH terms

• Alzheimer Disease

• NCT number: NCT03447613
• Study type: Observational
• Source: Shanghai 10th People's Hospital
• Status: Completed
• Start date: August 1, 2013
• Completion date: December 31, 2014