Developing Advanced Blood-Brain Barrier Permeability Imaging for Early AD

Status Completed

Clinical Trial Summary

Aging is the primary risk factor in aging-related dementia. An important initiating factor for the development and progression of cognitive impairment is disruption of the blood-brain barrier (BBB). BBB plays an important role in maintaining normal brain homeostasis and protecting neural tissues from toxins. It is hypothesized that such changes known to be common in aging and can be an early process that precedes Alzheimer's Disease (AD). The microvascular changes related to subtle BBB disruption can be measured with permeability-surface area (PS) derived from GRASP DCE-MRI acquired less than 10 minutes, and the patterns of increased PS in normal and abnormal aging are different.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Alzheimer Disease

Clinical Trial Details

NCT number	NCT03389698
Study type	Observational
Source	NYU Langone Health
Contact
Status	Completed
Phase
Start date	December 18, 2018
Completion date	July 11, 2023

View Details

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