Lexical Priming by Music in Alzheimer's Disease and Healthy Aging

Alzheimer Disease Clinical Trial

— PriMus  

Official title:

Lexical Priming by Music in Alzheimer's Disease and Healthy Aging

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT03342326
• Other study ID #: 1708117
• Secondary ID: 2017-A02686-47
• Status: Terminated
• Phase: N/A
• Start date: April 3, 2018
• Est. completion date: May 29, 2019

Study information

• Verified date: September 2020
• Source: Centre Hospitalier Universitaire de Saint Etienne
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

While verbal memory is quickly reached in the wake of Alzheimer's disease, the musical memory remains preserved until a late stage of the disease. This observation encouraged the development of music-based therapies in the management of neurocognitive and behavioral disorders that characterize Alzheimer's disease. In order to develop rehabilitation programs that effectively target cognitive functions to stimulate, it is necessary to understand the mechanisms underlying this beneficial effect of music on cognition.

Description:

The investigators study the stimulation by the song, material integrating language and music, and having an autobiographical value. The investigators measure the lexical priming capacity of the song, that is, its ability to activate and maintain lexical and semantic representations, which are threatened with alteration in the course of the disease.

This lexical priming effect by song is measured in patients with mild Alzheimer's disease and healthy volunteers during a single test session. In the first phase of the session, participants are exposed to familiar songs, presented in sung, spoken or instrumental form, whose popularity they evaluate. In the second phase, they perform two implicit memory tasks: a trigram completion task and a lexical decision task. These tests measure the facilitation of the processing of words evoked by songs in relation to words unrelated to songs, reflecting a "long-term" memory update of mnemic traces of primed words.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 58
• Est. completion date: May 29, 2019
• Est. primary completion date: May 29, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria for patients :

• Presence of diagnostic criteria for Alzheimer's disease

• Age = 65 years

• MMSE (Mini-mental state Examination) = 20

Exclusion Criteria for patient :

• Unstable clinical presentation or language presentation in the foreground

• Cognitive disorder of etiology different from that of Alzheimer's disease

Inclusion Criteria for volunteers :

• Age = 18 years

• Absence of neurological or psychiatric antecedents

• For those aged 65 or over: MMSE (Mini-mental state Examination) greater than or equal to 27; non-pathological performance against the 5 words of Dubois and the verbal fluency test.

Exclusion Criteria for volunteers :

• Visual or auditory disorders insufficiently corrected

• Oral or written expression in French insufficient to carry out tests

• Consumption of psychotropic drugs not stabilized

Related Conditions & MeSH terms

• Alzheimer Disease

Intervention

Other:
• Exposure to familiar songs
3 conditions : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5.
• Music Experience Questionnaire
questions about the past music training
• Implicit tasks memory
2 tests : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not.
• Questionnaires
Mini Mental State Examination, 5 words by Dubois and fluence verbal test

Locations

Country	Name	City	State
France	CHU de Saint Etienne	Saint-Étienne

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Saint Etienne

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Reaction time difference for the treatment of words that have been presented in sing condition in the exposure phase versus words presented in spoken condition.		Day 1
Secondary	Reaction time difference for processing words associated with songs presented by their melody alone versus new words (not presented in the exhibition phase).		Day 1