Alzheimer Disease Clinical Trial
Official title:
Association Between Cerebral Arterial Vascular Flow and Sleep Apnea in Neurodegenerative Alterations
Obstructive sleep apnea syndrome (OSAS) is a sleep-disordered breathing characterized by the
occurrence of repeated upper airway obstructions leading to airflow reduction (hypopnea) or
cessation (apnea). The apnea-hypopnea index (AHI) is the number of apneas and hypopneas per
hour of sleep. OSA patients often report cognitive complaints.
About 25% of the elderly population is affected by this syndrome with a drastic increase of
this rate among dementia patients. OSAS is considered to be an important risk factor for the
development of hypertension, heart disease and stroke.
Numerous studies pointed out the close relationship between sleep apnea and cognitive
impairment. To the investigators' knowledge, no trials have assessed the existence of a
relationship between the IAH index and the cerebral arterial blood flow rate
(macrocirculation). Developments in magnetic resonance imaging (MRI) provide new insights
into the quantitative study of blood flow through phase contrast MRI also called "flow MRI".
The main hypothesis tested in this study is the existence of a relationship between OSAS and
total cerebral arterial vascular inflow measured by PC-MRI (in mL/min) in the elderly
population.
- Primary outcome: The apnea/hypopnea index (measured by nocturnal respiratory polygraphy)
and total arterial flow rate (measured by PC-MRI)
- Secondary outcomes:
1. Measurement of arrhythmia
2. Measurement of arterial blood pressure
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