Alzheimer Disease Clinical Trial
The current study is planed to compare the efficacy of real (anodal and cathodal) vs sham
transcranial direct current stimulation (tDCS) applied over the left dorsolateral prefrontal
cortex (DLPFC) on cognitive functions and cortical excitability of patients with Alzheimer
disease (AD).
Thirty three with mild to moderate Alzheimer's disease (AD) patients (diagnosis of probable
AD according to the criteria of the National Institute of Neurological and Communicative
Disorders and Stroke Alzheimer Disease and Related Disorders Association [NINCDS-ADRDA] were
included in this study) were randomly classified into one of three groups (eleven for each
group). The first group received anodal tDCS over left DLPFC and 2rd group received cathodal
tDCS on the left DLPFC and the 3rd group received sham tDCS stimulation, daily for 10
consecutive days (5 days/week for 2 weeks). Minimental State Examination (MMSE),
psychometric assessment for cognitive functions (MMSE, Wechsler memory scale, Wechsler adult
Intelligent scale) were assessed before, after 10th sessions, and then after 1 and 2 month.
Cortical excitability was assessed in both hemispheres before and after the end of sessions.
Neurophysiological evaluations included resting and active motor threshold (rMT and aMT),
and cortical silent period (CSP).
At the time of recruitment, none of the patients taking antidepressants, or neuroleptic,
sedative-hypnotic drugs for at least two weeks before the assessment. All participants or
their caregivers will give informed consent before participation in the test and after full
explanation of the study protocol.
Outcome: The real group received (anodal and cathodal) tDCS are expected to have more
improvement on cognitive functions compared to sham tDCS group. tDCS is considered new
adjuvant non pharmacological therapeutic tool for management of AD patients with mild to
moderate degree dementia.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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