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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT01315717
Other study ID # 2009-A00533-54
Secondary ID
Status Completed
Phase N/A
First received March 10, 2011
Last updated September 21, 2016
Start date November 2009
Est. completion date May 2016

Study information

Verified date March 2011
Source University Hospital, Angers
Contact n/a
Is FDA regulated No
Health authority France: Ministry of Health
Study type Observational

Clinical Trial Summary

The purpose of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and moderate dementia stages).


Description:

Although gait disorders are frequently associated with Alzheimer's disease (AD), few studies have focused on their characterization and mechanism. Exploring the associations of the gait characteristics - more particularly the gait variability - with the cognitive performance of AD patients on one hand, and with the morphological brain abnormalities on the other hand, could be useful to understanding the mechanisms of gait disorders in AD.

The main objective of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and moderate dementia stages).


Recruitment information / eligibility

Status Completed
Enrollment 912
Est. completion date May 2016
Est. primary completion date May 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 60 Years and older
Eligibility Inclusion Criteria:

- Age = 60 years

- Able to walk without walking aid on 15 metres

- Score of Mini-Mental Examination (MMSE) > 10

- Written informed consent to participate in the study (or trustworthy person)

- Being affiliated to a social security regime

- Near visual acuity = 2/10

- Absence of severe depression (score in the 15-item Geriatric Depression Scale = 10)

Exclusion Criteria:

- Score of Mini-Mental Examination (MMSE) = 10

- Subject suffering from pre-existing impellent disturbances

- History of cerebrovascular accident or other cerebro-spinal pathology

- Poor workmanship of the written or oral French language

- Refusal of subject to be informed on possible hanging bare anomaly during study

- Use of walking aid

- Acute medical or surgical disease in the past 3 months

- Refusal to participate (or trustworthy person)

- Contra-indication to the achievement of a Magnetic Resonance Imaging

- Near visual acuity < 2/10

- Presence of severe depression (score in the 15-item Geriatric Depression Scale > 10)

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional


Locations

Country Name City State
France Angers University Hospital Angers

Sponsors (1)

Lead Sponsor Collaborator
University Hospital, Angers

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Stride-to-stride variability of stride time baseline No
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