Alzheimer Disease Clinical Trial
Official title:
Losing Sleep Over Alzheimer's Disease? Effects of Sleep Deprivation on Cerebrospinal Fluid Amyloid-beta Dynamics
Introduction: Alzheimer's disease (AD) is characterized by neurodegeneration of the brain in
the form of neurofibrillary tangles and plaques containing the amyloid-beta protein (Abeta).
Recent animal studies have shown that extended wakefulness is associated with increased
production of these Abeta proteins and that sleep leads to a marked fall in their
production.
Aim: The investigators aim to distinguish a similar effect of sleep disturbance on
cerebrospinal fluid (CSF) Abeta levels in humans, which may point out sleep disturbance as
an important factor in AD development.
Methods: a study in 26 healthy male volunteers, measuring CSF Abeta levels during a sleep
deprivation night and before and after a control night with unrestricted sleep.
Expected results: The investigators expect sleep deprivation to lead to an increase in CSF
Abeta levels, as compared to the levels in the control night.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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