Alzheimer Disease Clinical Trial
— C3LM-ILADOfficial title:
Comparison of 3 Learning Methods and Their Underlying Mechanisms to Improve Independent Living in the Activities of Daily Living in Alzheimer's Dementia: a Randomized Controlled Trial
This study is a comparison of 3 learning techniques, Errorless learning, modelling and trial
and error, in the relearning of IADL of Alzheimer patients from mild to moderately severe
dementia.
Tailored IADL will be chosen for each patient (n=300) and trained in individualized sessions
for 6 weeks.
This study focuses on the relationship between learning techniques, IADL and memory
processes, in a threefold way:
1. it will determine which of the of the three learning techniques (EL, MR, TE) will
improve most the (re)learning of instrumental skills in different dementia stages using
a randomized controlled trial;
2. it will explain the role of implicit and explicit memory mechanisms in the (re)learning
of IADL tasks; and
3. as a secondary objective, it will explore the possible drug treatment by behavioral
intervention interaction effects of the three learning techniques.
Status | Recruiting |
Enrollment | 300 |
Est. completion date | |
Est. primary completion date | March 2012 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 60 Years and older |
Eligibility |
Inclusion criteria: - Having a diagnosis of mild to moderately severe Alzheimer Dementia type with a MMSE score between 10 and 26; - Fulfill the DSM-IV-TR and NINCDS-ADRDA criteria for Alzheimer's dementia type (33;34); - Aged 60 and older; - Not able to complete without cue the proposed tasks during the screening interview. - Having a Social Security System Exclusion criteria: - MMSE < 10 or > 26 - Participants with severe deficits in alertness, - Deemed behavioral disturbances (e.g., such as high NPI irritability symptom as defined with a score of 6 or above out of a maximum score of 12), - Known medications that could interfere with the intervention (except AD medication, cf AD treatments). |
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
France | CHU de Nice Centre Mémoire | Nice |
Lead Sponsor | Collaborator |
---|---|
Department of Clinical Research and Innovation | Fondation Médéric Alzheimer, Institut National de la Santé Et de la Recherche Médicale, France |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The primary outcome of the intervention will be the performance and errors of participants. Each task is comparable as the assessment procedure remains the same across disease stages. | 2 hours - 2 times a week during 6 weeks | No | |
Secondary | Baseline neuropsychological assessments. Premorbid intelligence level will be estimated by the National Adult Reading Test (NART). The Mini Mental State Examination (MMSE) will be used to assessed cognitive status. | 3 times through the trial | No |
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