Alzheimer Disease Clinical Trial
Official title:
Evaluation of Apathy Using Attentional Reaction Test in Neurodegenerative Diseases
Apathy, defined as a lack of motivation in behaviour, cognition and affect, is common in
neurodegenerative diseases. Specific scales are available for the evaluation of apathy but
it lacks objective evaluation methods.
The aim of this study is to evaluate the changes in reaction time task according to the
presence or absence of reward stimulation and to assess the relation between these
performances and apathy scales.
MATERIAL: 13 patients with Mild Cognitive Impairment (MCI), 15 patients with Alzheimer's
disease (AD) and 91 elderly healthy subjects were enrolled. A computerized test using the
experiment software E-prime® was designed to assess reaction times (in ms) in different
experimental conditions after a training trial (neutral, stimulation, stress, stimulation
after stress, extinction) and relation between the performances to the test and the Apathy
Inventory (AI) scores (lack of initiative, lack of interest, emotional blunting) were
observed.
METHOD: Using a computerized test, each patient is asked to press a button (mouse of the
computer) each time the screen of the computer becomes completely white. After pressing the
button, a randomized colorized geometric figure appears on the screen, and disappears
automatically after a few seconds, replaced by a new white screen. Reaction time (in ms)
between a white screen and a press of the button is analysed. After a training trial,
reaction times are analysed in different experimental conditions: neutral - stimulation1
(patient gets points when pressing the button) - stress (alarm) - stimulation2 (patient gets
points when pressing, after the stress trial) - extinction (similar to neutral condition).
;
Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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