Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles

Alveolar Echinococcosis Clinical Trial

Official title:

Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles in Patients With Inoperable Alveolar Echinococcosis Using PET-CT and EmII/3-10 Serology

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00658294
• Other study ID #: EK-1351
• Status: Completed
• Phase: N/A
• First received: April 8, 2008
• Last updated: October 16, 2017
• Start date: January 2008
• Est. completion date: December 31, 2012

Study information

• Verified date: October 2017
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to evaluate PET-CT and EmII/3-10 serology as potential markers to assess the parasitocidal effect of benzimidazoles

• Trial with medicinal product

Recruitment information / eligibility

• Status: Completed
• Enrollment: 34
• Est. completion date: December 31, 2012
• Est. primary completion date: December 31, 2012
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion criteria:

• Patients with inoperable alveolar echinococcosis

• With negative PET-CT

• EmII/3-10 serology under long-term chemotherapy with benzimidazoles

Exclusion criteria:

• Positive PET-CT

• Positive EmII-3-10 Serology

• No compliance

• Reduced life expectancy

• Pregnancy

Related Conditions & MeSH terms

• Alveolar Echinococcosis
• Echinococcosis, Hepatic

Intervention

Other:
• Stop treatment

Locations

Country	Name	City	State
Switzerland	University Hospital Zurich	Zurich

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

References & Publications (1)

Ammann RW, Stumpe KD, Grimm F, Deplazes P, Huber S, Bertogg K, Fischer DR, Müllhaupt B. Outcome after Discontinuing Long-Term Benzimidazole Treatment in 11 Patients with Non-resectable Alveolar Echinococcosis with Negative FDG-PET/CT and Anti-EmII/3-10 Se — View Citation