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Vit D and Post-extractive Bone Turnover

Vitamin D Deficiency Clinical Trial

Official title:
The Effect of Vit D on Post-extraction Site Bone Remodeling and Regeneration After 4 Months: A Prospective Clinical Trial

Clinical Trial Summary

The aims of the study was to correlate the extent of the dimensional alveolar bone changes after tooth extraction and contextual guided bone regeneration with serum vit D levels in 14 patients. Moreover, at 4 months, a small bone sample was collected in order to correlate histological and immunohistochemical parameters of bone with vit D serum levels.

Clinical Trial Description

The study included 14 patients requiring tooth extraction and subsequent post-extraction bone regeneration with heterologous graft material of porcine origin. Four months after extraction, dental implants were placed, and insertion torque values (ITV) and implant stability quotients (ISQ) were recorded. During implant placement, a small bone sample was collected for histological analysis. The aim of the study was to analyze the correlation between serum vitamin D levels and post-extraction bone volume contraction, collagen type I (Col1A1), osteocalcin, osteopontin, runt-related transcription factor 2 (Runx2), ITV, ISQ, Newly Formed Bone Tissue (NFBT). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06412705
Study type Interventional
Source Studio Odontoiatrico Associato Dr. P. Cicchese e L. Canullo
Contact
Status Completed
Phase N/A
Start date October 2, 2023
Completion date April 30, 2024
View Details
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