Alveolar Bone Loss Clinical Trial
Official title:
The Influence of Mucosal Tissue Thickness on Soft and Hard Tissue Changes Around Implants. A Randomized Controlled Clinical Study
Crestal bone and soft tissue stability around implants is an important issue in implant dentistry. Initial vertical mucosal tissue thickness was shown to be one of the factors having impact on bone stability. However, there is lack of data in the literature regarding the relationship between mucosal thickness and marginal bone loss around implants. Berglundh and Lindhe in an animal study reported that thin mucosal tissue causes significantly more crestal bone resorption around implants. In addition, clinical research regarding the effects of tissue thickness on bone and soft tissue stability around implants is lacking. The aim of this clinical study is to evaluate the influence of mucosal tissue thickness on soft and hard tissue changes around implants.
Status | Recruiting |
Enrollment | 140 |
Est. completion date | April 2018 |
Est. primary completion date | February 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: 1. >18 years of age 2. no medical contraindication for implant surgery 3. missing teeth in the posterior mandibular area requiring two implants supported three unit bridge prosthetic restoration 4. fully healed bone sites (at least 3 months after extraction) 5. minimum of 6mm bone width and 10 mm bone height above inferior alveolar canal 6. healthy soft tissue 7. minimum 2mm keratinized gingiva 8. no bone augmentation procedures before and during implant placement. Exclusion Criteria: - The patients will be excluded if they will not meet inclusion criteria and additionally have 1. poor oral hygiene 2. uncontrolled periodontitis 3. smoking |
Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Screening
Country | Name | City | State |
---|---|---|---|
Turkey | Cukurova University Faculty of Dentistry | Adana |
Lead Sponsor | Collaborator |
---|---|
Cukurova University | Dentsply Implants |
Turkey,
Bengazi F, Lang NP, Caroprese M, Urbizo Velez J, Favero V, Botticelli D. Dimensional changes in soft tissues around dental implants following free gingival grafting: an experimental study in dogs. Clin Oral Implants Res. 2015 Feb;26(2):176-82. doi: 10.1111/clr.12280. Epub 2013 Oct 24. — View Citation
Berglundh T, Lindhe J. Dimension of the periimplant mucosa. Biological width revisited. J Clin Periodontol. 1996 Oct;23(10):971-3. — View Citation
Linkevicius T, Apse P, Grybauskas S, Puisys A. Influence of thin mucosal tissues on crestal bone stability around implants with platform switching: a 1-year pilot study. J Oral Maxillofac Surg. 2010 Sep;68(9):2272-7. doi: 10.1016/j.joms.2009.08.018. — View Citation
Linkevicius T, Apse P, Grybauskas S, Puisys A. Reaction of crestal bone around implants depending on mucosal tissue thickness. A 1-year prospective clinical study. Stomatologija. 2009;11(3):83-91. — View Citation
Linkevicius T, Apse P, Grybauskas S, Puisys A. The influence of soft tissue thickness on crestal bone changes around implants: a 1-year prospective controlled clinical trial. Int J Oral Maxillofac Implants. 2009 Jul-Aug;24(4):712-9. — View Citation
Puisys A, Linkevicius T. The influence of mucosal tissue thickening on crestal bone stability around bone-level implants. A prospective controlled clinical trial. Clin Oral Implants Res. 2015 Feb;26(2):123-9. doi: 10.1111/clr.12301. Epub 2013 Dec 9. — View Citation
Puisys A, Vindasiute E, Linkevciene L, Linkevicius T. The use of acellular dermal matrix membrane for vertical soft tissue augmentation during submerged implant placement: a case series. Clin Oral Implants Res. 2015 Apr;26(4):465-70. doi: 10.1111/clr.12401. Epub 2014 Apr 30. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Marginal bone loss around implant | The measurements will be performed using Image J analysis software program (Image J version 1.44-National Institutes of Health, NIH) by an examiner who is unaware of the group assignment. The intra-examiner and inter-examiner agreement will be determined. | The mean change in marginal bone loss from baseline marginal bone level at implant placement to 12 months of implant loading. | Yes |
Secondary | Soft tissue changes around implant | The measurements will be performed clinically by an examiner who is unaware of the group assignment. | Periodontal indexes will be evaluated at 18 weeks after implant placement at prosthetic delivery. | Yes |
Secondary | Soft tissue changes around implant | The measurements will be performed clinically by an examiner who is unaware of the group assignment. | Periodontal indexes will be evaluated at 6 months after implant loading | Yes |
Secondary | Soft tissue changes around implant | The measurements will be performed clinically by an examiner who is unaware of the group assignment. | Periodontal indexes will be evaluated at 12 months after implant loading. | Yes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT05470673 -
Autogenous Demineralized Dentin Graft Combined With Injectable PRF + Metronidazole Versus Autogenous Demineralized Dentin Graft Alone for Alveolar Ridge Preservation
|
N/A | |
Completed |
NCT02515058 -
Ridge Preservation Following Tooth Extraction Using Two Mineralized Cancellous Bone Allografts
|
N/A | |
Enrolling by invitation |
NCT02209311 -
Effectiveness and Safety of Method of Maxilla Alveolar Process Reconstruction Using Synthetic Tricalcium Phosphate and Autologous MMSCs
|
Phase 1/Phase 2 | |
Completed |
NCT02602223 -
Comparison of Amnion Chorion Membrane vs. Dense Polytetrafluoroethylene Membrane in Ridge Preservation Procedures
|
Phase 2 | |
Completed |
NCT02255149 -
A Feasibility Study for Growth Bone Vertically With Titanium Mesh and Allograft in Lower Posterior Jaw
|
N/A | |
Recruiting |
NCT05674331 -
Clinical, Radiographical, Histological Evaluation and Blood Flow Analysis of Alveolar Ridge Preservation
|
N/A | |
Recruiting |
NCT06081296 -
Dimensional Changes in Alveolar Ridge Preservation
|
N/A | |
Completed |
NCT03944811 -
Bone Height Gain Following Transcrestal Sinus Floor Elevation Using Piezoelectric Surgery Versus The Conventional Osteotome Technique
|
N/A | |
Completed |
NCT03045458 -
Associations of Alveolar Bone Loss and Interleukin-1β Levels in One and Two Stage Surgical Procedures
|
N/A | |
Completed |
NCT05595746 -
Radiological Bone Loss on Different Levels of Dental Implants
|
N/A | |
Completed |
NCT03357705 -
Effectiveness in Limiting the Need to Elevate the Maxillary Sinus
|
N/A | |
Recruiting |
NCT05311735 -
Mineralized and Partial Demineralized Dentin Graft Compared to FDBA
|
N/A | |
Completed |
NCT05494476 -
Stability of the Marginal Bone Around Subcrestal Implants
|
N/A | |
Not yet recruiting |
NCT05536479 -
Evaluation of Autogenous Stored Versus Autogenous Fresh Mineralized Dentin Graft for Alveolar Ridge Preservation
|
N/A | |
Active, not recruiting |
NCT02275767 -
Histological Evaluation of Healing Following Ridge Preservation Using a Combined Cortical/Cancellous Mineralized Freeze-Dried Bone Allograft
|
N/A | |
Active, not recruiting |
NCT02120053 -
Interest of Bone Substitute Material in Immediate Complete Denture
|
Phase 2/Phase 3 | |
Completed |
NCT01728844 -
GUIDOR® Growth Factor Enhanced Bone Graft Substitute for the Treatment of Periodontal Defects 6-months Post-Surgery
|
N/A | |
Terminated |
NCT00991965 -
Localized Alveolar Ridge Augmentation With Dental Implant
|
N/A | |
Terminated |
NCT00991432 -
Localized Alveolar Ridge Augmentation With Space Maintenance Devices
|
N/A | |
Completed |
NCT03149172 -
Comparison of Post Tooth Extraction Healing Using Different Xenograft Materials
|
N/A |