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Clinical Trial Summary

The main aim of this study is to learn if fazirsiran reduces liver scarring (fibrosis) compared to placebo. Other aims are to learn if fazirsiran slows down the disease worsening in the liver, to get information on how fazirsiran affects the body (called pharmacodynamics), to learn if fazirsiran reduces other liver injury (inflammation) and the abnormal Z-AAT protein in the liver, to get information on how the body processes fazirsiran (called pharmacokinetics), to test how well fazirsiran works compared with a placebo in improving measures of liver scarring including imaging and liver biomarkers (substances in the blood that the body normally makes and help show if liver function is improving, staying the same, or getting worse) as well as to check for side effects in participants treated with fazirsiran compared with those who received placebo. Participants will either receive fazirsiran or placebo. Liver biopsies, a way of collecting a small tissue sample from the liver, will be taken twice during this study.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05677971
Study type Interventional
Source Takeda
Contact Takeda Contact
Phone 1-877-825-3327
Email medinfoUS@takeda.com
Status Recruiting
Phase Phase 3
Start date March 6, 2023
Completion date March 31, 2029

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