Genetics of Alpha Thalassemia in Israeli Ethnic Groups

Alpha Thalassemia Clinical Trial

Official title: Haplotype Analysis of Alpha Globin Genes in Israeli Ethnic Groups

Status Completed

Clinical Trial Summary

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin genes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.

Clinical Trial Description

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin polymorphisms to determine the haplotypes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction. ;

Related Conditions & MeSH terms

• Alpha Thalassemia
• alpha-Thalassemia
• Thalassemia

• NCT number: NCT00159029
• Study type: Observational
• Source: Hadassah Medical Organization
• Status: Completed
• Phase: N/A
• Start date: April 1, 2004
• Completion date: July 1, 2017