A Study to Evaluate Efficacy & Safety of VX-864 in Participants With

See also
Status	Clinical Trial	Phase
Completed	`NCT02547532` - Microbioma in Sputa From COPD With Alpha-1 Antitrypsin Deficiency
Completed	`NCT01615484` - Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability	N/A
Completed	`NCT00005292` - Alpha1-antitrypsin Deficiency Registry	N/A
Withdrawn	`NCT02900183` - Safety, Tolerability and Effect of ARC-AAT Injection on Circulating and Intrahepatic Alpha-1 Antitrypsin Levels	Phase 2
Terminated	`NCT02502201` - Environment Effect on Six-Minute Walk Test Performance	N/A
Completed	`NCT01810458` - Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD)
Active, not recruiting	`NCT04262284` - Respreeza® Self-administration and Learning Program (AmAREtTI Study)
Recruiting	`NCT06186492` - A Phase 1 Research Study to Evaluate Safety, Tolerability, and Pharmacokinetics of WVE-006 in Healthy Participants With Wild-type AAT Expression (RestorAATion-1)	Phase 1
Recruiting	`NCT06405633` - A Phase 1b/2a, Open-label Single Ascending Doses and Multiple Ascending Doses Study in Participants With Pi*ZZ AATD	Phase 1/Phase 2
Completed	`NCT01054339` - Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency	Phase 2
Completed	`NCT03815396` - Phase 1 Study to Assess the Safety, PK and PD of INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency	Phase 1
Completed	`NCT03008915` - Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency	Phase 2
Completed	`NCT01419158` - Prevalence of Alpha-1 Antitrypsin Deficiency in Chronic Obstructive Pulmonary Disease (COPD)	N/A
Recruiting	`NCT00500123` - The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study
Completed	`NCT05727800` - A Phase 1, First-in-human Study of VX-668	Phase 1
Completed	`NCT02810327` - Alpha-1 Carrier Genomics Study
Terminated	`NCT02363946` - A Study of ARC-AAT in Healthy Volunteer Subjects and Patients With Alpha-1 Antitrypsin Deficiency (AATD)	Phase 1
Completed	`NCT03804021` - Long-Term Follow-up Study of ADVM-043
Active, not recruiting	`NCT02014415` - Alpha-1 Antitrypsin Deficiency Adult Liver Study
Terminated	`NCT01241942` - Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability	N/A

NCT number	NCT05643495
Study type	Interventional
Source	Vertex Pharmaceuticals Incorporated
Contact
Status	Active, not recruiting
Phase	Phase 2
Start date	February 23, 2023
Completion date	December 2024

A Study to Evaluate Efficacy and Safety of VX-864 in Participants With the PiZZ Genotype

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms