Alpha 1-Antitrypsin Deficiency Clinical Trial
Official title:
Alpha-1 Research Registry Protocol
The Alpha-1 Research Registry is a confidential database made up of individuals diagnosed with Alpha-1 Antitrypsin Deficiency (Alpha-1) and individuals identified as Alpha-1 carriers. The Registry was established to facilitate research initiatives and promote the development of improved treatments and a cure for Alpha-1.
The purpose and goal of the Alpha-1 Research Registry (Registry, or group of patients) will be to obtain uniform, longitudinal (over the course of time), complete and accurate data that can be organized, and made available for the public to query. The collective number of Registry members enables investigators to enroll sufficient subjects to carry out their studies. The community benefits from having more research and potential therapies performed in their disease. Regular updates from patients will give objective data-points to measure the progression of disease. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
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Baby Detect : Genomic Newborn Screening
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| Recruiting |
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The Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin Degradation
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N/A | |
| Completed |
NCT03636347 -
A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo.
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Phase 2 | |
| Completed |
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Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor)
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Phase 4 | |
| Completed |
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Study of DCR-A1AT in Healthy Adult Volunteers
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Phase 1 | |
| Completed |
NCT05579431 -
A Phase 1, First-in-human Study of VX-634
|
Phase 1 | |
| Recruiting |
NCT05856331 -
Study of INBRX-101 Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema
|
Phase 2 | |
| Suspended |
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Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)
|
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| Completed |
NCT02168686 -
Safety Dose Finding Study of ADVM-043 Gene Therapy to Treat Alpha-1 Antitrypsin (A1AT) Deficiency
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04204252 -
Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD
|
Phase 3 | |
| Completed |
NCT00067756 -
4-PBA: Will it Increase the Level of Alpha 1-Antitrypsin(AAT) in Persons With AAT Deficiency?
|
Phase 2 | |
| Not yet recruiting |
NCT06389877 -
A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)
|
Phase 1/Phase 2 | |
| Completed |
NCT00295061 -
Comparison of Pharmacokinetic, Safety, Tolerability of Alpha-1 MP and Prolastin In Alpha1-antitrypsin Deficient Adults
|
Phase 3 | |
| Completed |
NCT00001462 -
Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals
|
N/A | |
| Active, not recruiting |
NCT05297812 -
Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease
|
||
| Completed |
NCT03114020 -
Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency
|
Phase 2 | |
| Completed |
NCT00460096 -
Phase II/III Study of an Alpha-1 Proteinase Inhibitor (Kamada-API) in Individuals With Alpha-1 Antitrypsin Deficiency
|
Phase 2/Phase 3 | |
| Completed |
NCT00377416 -
Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
|
Early Phase 1 | |
| Terminated |
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Study of Genotype and Phenotype in Patients With Alpha 1-Antitrypsin Deficiency
|
N/A | |
| Completed |
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Study of ARO-AAT in Normal Adult Volunteers
|
Phase 1 |