The Effect of 0.5% Roxithromycin Lotion for Androgenetic Alopecia

Status Active, not recruiting

Clinical Trial Summary

The purpose of this study is exploiting the new drugs for androgenetic alopecia because there are still no effective and safe topical drug for androgenetic alopecia. Roxithomycin is one of the macrolide antibiotics that has immunomodulatory effects. We firstly found that roxithromycin increases the rate of murine and human hair follicle elongation in vitro. Therefore, we apply this drug on this disease therapy.

Clinical Trial Description

The topical therapy for androgenetic alopecia is still not enough to improve cosmetically. Thereforem we try to find new effective and safe topical therapy for this disease. Roxithromycin has not only antibacterial action but also immunomodulatory and anti-inflamatory potency. For example, roxitromycin inhibits T cell responces to mitogens and production of cytokines, IL-2 and IL-5. We firstly found that roxitromycin increased human and murine hair elongation in vitro to inhibit apoptosis of hair bulb. Then, we wish to apply roxithromycin on the therapy for androgenetic alopecia. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00197379
Study type	Interventional
Source	Hamamatsu University
Contact
Status	Active, not recruiting
Phase	N/A
Start date	May 2005
Completion date	January 2007

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04953416` - Fractional Non-ablative Laser for the Treatment of Hair Loss	N/A
Completed	`NCT01929330` - Bioequivalence Study of Dutasteride Five 0.1 mg and One 0.5 mg Soft Gelatin Capsules in Healthy Male Volunteers	Phase 1
Recruiting	`NCT05213936` - Scalp Cooling for Chemotherapy-Induced Alopecia in Patients of Color	N/A
Completed	`NCT02919735` - Efficacy, Safety and Tolerability of CG428 Cutaneous Solution on Chemotherapy Induced Alopecia; Controlled Study (ELAN)	Phase 2
Recruiting	`NCT02591823` - Hair Fall in Patients on Low Dose Methotrexate	N/A
Enrolling by invitation	`NCT01651689` - Hair Counts From Vertical and Horizontal Sections of Scalp Biopsy SPecimens in Thai Population With Alopecia	N/A
Completed	`NCT01189279` - Safety and Pharmacokinetics Study of New Formulation of Bimatoprost in Patients With Alopecia	Phase 1
Recruiting	`NCT01111981` - Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia	Phase 4
Terminated	`NCT01385839` - Efficacy of Hair Transplantation Compared With Hypodermic Needle Irritation in Alopecia Areata	N/A
Active, not recruiting	`NCT03382184` - Fractional Photothermolysis for Hair Follicle Induction	Early Phase 1
Not yet recruiting	`NCT05544448` - In Vitro Effect Study of Interleukin-2 Muteins on Regulatory T Cells of Patients With Different Autoimmune, Allo-immune or Inflammatory Diseases	N/A
Completed	`NCT03689452` - The Effect of Platelet Rich Plasma on Non-scarring Alopecia	N/A
Recruiting	`NCT00801086` - Efficacy Study of Tempol to Prevent Hair Loss From Radiotherapy to the Brain	Phase 2
Completed	`NCT06095739` - Study to Investigate the Effectiveness of a Topical Cosmetic Formulation DA-OTC-002	N/A
Completed	`NCT05587699` - The Parallel Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of CKD-843 A	Phase 1
Completed	`NCT03351322` - ENERGI-F701 for Female Hair Loss Treatment	Phase 2
Completed	`NCT01590238` - Enhancing Hair Density With Platelet Rich Fibrin Matrix (PRFM)	Phase 3
Not yet recruiting	`NCT01557491` - Hair Regrowth After Bicoronal Incision	N/A
Terminated	`NCT02935569` - Compression Headband Use to Prevent Hair Loss During Whole Brain Radiotherapy	N/A
Completed	`NCT00515762` - Prevention of Persistent Alopecia Following Docetaxel by Means of Scalp Cooling	Phase 2