Open Label Study of ATI-50002 Topical Solution Administered to Adult Subjects With Eyebrow Loss Due to Alopecia Areata

Alopecia Areata Clinical Trial

Official title:

An Open-Label Pilot Study of the Safety, Tolerability and Efficacy of ATI-50002 Topical Solution Administered Twice-Daily in Adult Subjects With Eyebrow Loss Due to Alopecia Areata, Alopecia Universalis or Alopecia Totalis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03551821
• Other study ID #: ATI-50002-AAB-201
• Status: Completed
• Phase: Phase 2
• Start date: April 11, 2018
• Est. completion date: November 6, 2018

Study information

• Verified date: October 2019
• Source: Aclaris Therapeutics, Inc.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main objective of this study is to assess the safety, tolerability and efficacy of ATI-50002 Topical Solution in subjects with unilateral or bilateral loss of eyebrow hair due to alopecia areata (AA), alopecia universalis (AU) or alopecia totalis (AT).

Description:

This is an open-label study which will be conducted at 1 to 2 sites.

Subjects will be required to have a clinical diagnosis of AA, AU or AT with unilateral or bilateral loss of eyebrow hair.

Subjects will apply study medication to the entire affected eyebrow(s), twice-daily for 24 weeks.

Safety and tolerability will be evaluated throughout the study.

The duration of the study participation is anticipated to be a maximum of 233 days.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1
• Est. completion date: November 6, 2018
• Est. primary completion date: November 6, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Subject is at least 18 years of age.

2. Subject has, based on a subject history and clinical examination, a clinical diagnosis of AA, AU or AT with no eyebrow hair in the affected area(s) and no eyebrow regrowth over the previous 6 months. Affected area is defined as the area(s) of eyebrow hair loss identified at Baseline.

3. Subject has a Clinician Eyebrow Assessment score of 0 for at least one eyebrow.

4. Subject has a Subject Eyebrow Assessment score of 0 for at least one eyebrow.

5. Subject has a duration of the current episode of AA, AU or AT with unilateral or bilateral loss of eyebrow hairs (with at least one distinct patch of >30% loss of eyebrow hair) for at least 6 months and no more than seven years prior to Visit 1.

6. Subjects who are Women of Childbearing Potential (WOCBP) must have a negative serum pregnancy test at Screening and a negative urine pregnancy test at Baseline and agree to use a highly effective method of birth control for the duration of the study and for 30 days after last study medication application.

7. Subject is non-pregnant and non-lactating and not planning a pregnancy during the duration of the study and for 30 days after the last study medication application.

8. Subject is in good general health and free of any known disease state or physical condition which, in the opinion of the investigator, would interfere with the study requirements or put the subject at undue risk by study participation.

9. Subject is willing and able to follow all study instructions and to attend all study visits.

10. Subjects taking hormonal replacement therapy must have been on the same dose for at least 6 months prior to Visit 1 and must agree to maintain the same dose for the duration of the study and for 90 days after the last study medication application.

11. Subjects taking thyroid replacement therapy must have been on the same dose for at least 6 months prior to Visit 1 and must agree to maintain the same dose for the duration of the study.

12. Subject agrees to refrain from any eyebrow removal (e.g.¸ plucking, threading, etc.) for the duration of the study.

13. Subject agrees to refrain from any cosmetic surgery (e.g., piercing, tattooing, etc.), on the treatment areas, for the duration of the study.

14. Subject can comprehend and is willing to sign an Informed Consent Form (ICF).

15. Sexually active male subjects must agree to use a barrier method of contraception from the first application of study medication to at least 30 days after the last application of study medication

Exclusion Criteria:

1. Subject has, in the opinion of the investigator, permanent eyebrow loss attributed to causes other than AA, AU or AT such as overgrooming, or scarring hair loss.

2. Subject currently has, or has a history of, skin disease in the eyebrow area (e.g., psoriasis, seborrheic dermatitis, etc.) that, in the opinion of the investigator, would interfere with the study medication application or study assessments.

3. Subject currently has, or has a history of, severe, progressive or uncontrolled autoimmune, metabolic, endocrinologic, renal, hepatic, gastrointestinal, pulmonary, cardiovascular, genitourinary (i.e., renal disease), hematological disease, neurologic or cerebral disorders, infectious disease or coagulation disorders that, in the opinion of the investigator, put the subject at undue risk by study participation.

4. Subject currently has, or has a history of, proven or suspected systemic or cutaneous malignancy and /or lymphoproliferative disease, other than a history of adequately treated, well healed and completely cleared non-melanoma skin cancers (e.g. basal or squamous cell carcinoma) treated successfully at least one year prior to Visit 1.

5. Subject currently has evidence of active or latent bacterial infection, including tuberculosis, or viral infections at the time of enrollment or a history of incompletely treated or untreated tuberculosis. Subjects who have completed therapy for latent tuberculosis may participate.

6. Subject has a history of serious local infection (e.g., cellulitis, abscess) or a systemic infection, including but not limited to, pneumonia or septicemia, within 12 weeks prior to Visit 1. Subjects on an antibiotic for a nonserious, acute local infection must complete the antibiotic course prior to enrollment in the study.

7. Subjects positive for HIV, Hepatitis B or C.

8. Subject currently has or has a known history of herpes zoster or cytomegalovirus (CMV) within 8 weeks prior to Visit 1.

9. Subject has a history of frequent outbreaks of Herpes Simplex Virus defined as 4 or more episodes per year.

10. Subject has any history of eyebrow tattooing, or microblading that in the opinion of the investigator would interfere with the assessment of safety or efficacy.

11. Subject has used any semi-permanent eyebrow coloring (e.g., tinting, dying, etc.) within 6 months prior to Visit 1 that in the opinion of the investigator would interfere with the assessment of safety or efficacy.

12. Clinically significant laboratory abnormalities at Screening that, in the opinion of the Investigator, would make the subject a poor candidate for the study.

13. Subjects with absolute neutrophil count <1,000/mm3, or platelet count <50,000/ml.

14. Subject used any of the following therapies within the specified period prior to Visit 1:

Systemic therapies:

• Disease Modifying Anti-Rheumatic Drugs (DMARDS), Biologics or immunosuppressants, such as: anakinra, adalimumab, azathioprine, glucocorticosteroids, cyclosporine, etanercept, infliximab, methotrexate, TNF inhibitors, ustekinumab, secukinumab, ixekizumab, certolizumab pegol: 4 weeks or 5 half-lives whichever is longer

• Oral retinoids: 12 weeks

• Plaquenil: 8 weeks

• JAK inhibitors (oral or topical): 1 year

• Intralesional steroids on the eyebrow area: 4 weeks

Topical therapies on the eyebrow area:

• Phototherapy, Laser Therapy : 12 weeks

• Anthralin, bimatoprost, glucocorticosteroids, diphencyprone, diphenylcycloprophenone (DPCP), Squaric acid dibutyl ester (SADBE), minoxidil, pimecrolimus, tacrolimus: 4 weeks

• Topical treatments (prescription and over-the-counter) that contain retinoids, retinol, alpha hydroxy acids (e.g. glycolic, lactic acids) and beta hydroxy acids (e.g. salicylic acid) on and around the eyebrow area: 4 weeks

15. Subject has a history of sensitivity to any of the ingredients in the study medication.

16. Subject has participated in an investigational drug or device trial in which administration of an investigational study drug or device occurred within 30 days or 5 half-lives (whichever is longer) prior to Visit 1. Subjects who have participated in a study of an investigational drug, device or biologic agent for alopecia areata (AA, AU or AT) within 1 year of screening will be eligible to participate only with individual permission from the Medical Monitor.

17. History of or current alcohol or drug abuse within 2 years of assessment for study enrollment.

18. Screening ECG findings of:

• QTcF >450msec for males or >470msec for females (use of the ECG algorithm is acceptable for this purpose)

• Heart rate < 45 or > 100 beats/minutes (inclusive)

• Rhythm disturbance other than sinus arrhythmia or ectopic supraventricular rhythm (ectopic atrial rhythm)

• Conduction disturbance including PR >240msec, pre-excitation (delta wave and PR <120msec), second degree or higher AV block

• Acute or chronic signs of ischemia

• Left Bundle Branch Block

• Prior myocardial infarction

Related Conditions & MeSH terms

• Alopecia
• Alopecia Areata
• Alopecia Totalis
• Alopecia Universalis

Intervention

Drug:
• ATI-50002
Topical Solution

Locations

Country	Name	City	State
United States	Aclaris Investigator Site	Boynton Beach	Florida

Sponsors (1)

Lead Sponsor	Collaborator
Aclaris Therapeutics, Inc.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Clinician's Eyebrow Assessment	Determination of the amount of hair in the affected area.; Clinician's Eyebrow Assessment; Grade Descriptor 0 No eyebrow hair: No terminal hairs are visible in the affected area(s); A little eyebrow hair: Occasional terminal hairs are visible in the affected area(s); Some eyebrow hair: Numerous terminal hairs are visible in the affected area(s); Most eyebrow hair: Mostly complete eyebrow regrowth with terminal hair in the affected area(s); Full eyebrow hair: Complete eyebrow regrowth with terminal hair in the affected area(s)	Six months
Secondary	Subject's Eyebrow Assessment	Determination of the amount of hair in the affected area.; Subject's Eyebrow Assessment Grade Descriptor 0 No eyebrow hair: No thick, coarse hairs are visible in the affected area(s); A little eyebrow hair: A few thick, coarse hairs are visible in the affected area(s); Some eyebrow hair: Numerous thick, coarse hairs are visible in the affected area(s); Most eyebrow hair: The majority of the affected area(s) of the eyebrow is covered in thick, coarse hairs; Full eyebrow hair: The affected area(s) of the eyebrow is fully covered in thick, coarse hairs	Six months