Alopecia Areata Clinical Trial
Official title:
Evaluating PAI-1 Expression in the Hair Follicles of Patients With Non-scarring Hair Loss.
NCT number | NCT02548689 |
Other study ID # | STU00103009 |
Secondary ID | |
Status | Terminated |
Phase | |
First received | |
Last updated | |
Start date | July 2015 |
Est. completion date | June 2021 |
Verified date | June 2022 |
Source | Northwestern University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This study will investigate whether subjects who suffer from hair loss have increased levels of PAI-1 compared to age-matched control subjects. The level of PAI-1 expression will be determined in subjects without hair loss and in subjects with non-scarring hair loss, including androgenetic alopecia, telogen effluvium and alopecia areata.
Status | Terminated |
Enrollment | 10 |
Est. completion date | June 2021 |
Est. primary completion date | June 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility | Inclusion Criteria: - Age-matched control subjects who do not have a history of hair loss - A clinical and pathologic diagnosis of androgenetic alopecia, telogen effluvium, alopecia areata or normal scalp skin - All subjects must have given signed, informed consent prior to registration in study Exclusion Criteria: - History of previous hair transplantation - Current and past use of medications topically on the scalp - Clinical or pathologic diagnosis of a scarring alopecia - History of inflammatory conditions of the scalp such as psoriasis |
Country | Name | City | State |
---|---|---|---|
United States | Northwestern University Department of Dermatology | Chicago | Illinois |
Lead Sponsor | Collaborator |
---|---|
Northwestern University |
United States,
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* Note: There are 23 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | PAI-1 expression level in scalp skin biopsy samples | Tissue PAI-1 expression levels will be determined by immunohistochemistry, a three-layer biotin-strepavidin system. Positive PAI-1 expression per total tissue area will be quantified using the color-picker function in imaging software.The PAI-1 expression found in normal scalps will be compared to those found in scalps with hair loss. | Baseline |
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