Allogenic Disease Clinical Trial
Official title:
Matched-Status Exercise Program in Patients Undergoing Myeloablative Allogeneic Blood and Marrow Transplantation: A Feasibility Study
Blood and marrow transplantation (BMT) is commonly used in the treatment of oncologic and
hematologic disorders. Patients undergoing Hematopoietic stem cell transplantation (HSCT) are
screened for functional status among other criteria to ensure that they are able to endure
the rigorous treatment involved during Hematopoietic stem cell transplantation (HSCT). The
patient entering the transplant process is possibly already functionally compromised from
their disease, prior cancer treatment, and possible other co-morbidities. Additional factors
of the transplantation that compromise the independent functional status of the patient
include the high dose preparative regimen, pancytopenia, steroid-related side effects,
hospitalization, transplantation complications such as infections, pulmonary alterations,
acute and chronic Graft-versus-host Disease (GVHD), pain, decreased nutritional input, and
other sequelae of transplantation.
Physical Therapy has been utilized in this population primarily as a supportive therapy to
prevent and limit the patient's functional decline. Studies have addressed general and
aerobic exercise in this population but there is a paucity of research investigating the
benefits of a strength-training program, particularly performed in weight-bearing, in
attenuating the detrimental effects of the transplantation on functional status.
This is a feasibility study questioning if an exercise program including weight-bearing
strengthening exercises and cardiovascular exercise is practical for the patients to carry
out as inpatients. The study will also preliminarily determine if this exercise program
influences functional outcomes and level of fatigue. Such outcome measures will include 1)
FiveTimes Sit-To-Stand Test, 2) Six-Minute Walk Test, 3) stair performance, 4) Functional
Assessment of Cancer Therapy-Bone Marrow Transplantation (FACT-BMT) and Functional Assessment
of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Scales.
The study population will include patients with lymphomas and acute leukemias undergoing
matched-related donor allogeneic myeloablative Blood and marrow transplantation (BMT).
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
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A Study to Assess Safety and Feasibility of Direct Infusions of Donor-derived Virus-specific T-cells in Recipients of Hematopoietic Stem Cell Transplantation With Post-transplant Viral Infections Using the Cytokine Capture System®
|
Phase 2 | |
| Recruiting |
NCT02829216 -
Graft-versus-host Disease Associated Myelosuppression
|
N/A |