Prospective Evaluation of Disparities in Provision of Allogeneic Transplantation

Allogeneic Transplantation Clinical Trial

Official title:

Prospective Evaluation of Disparities in Provision of Allogeneic Transplantation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06450353
• Other study ID #: 2024-0253
• Secondary ID: NCI-2024-04790
• Status: Recruiting
• Start date: May 31, 2024
• Est. completion date: June 1, 2029

Study information

• Verified date: June 2024
• Source: M.D. Anderson Cancer Center
• Contact: Warren Fingrut, MD
• Phone: (832) 387-8363
• Email: wbfingrut[@]mdanderson.org
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To look at the effect of a recipient's ancestry and socio-economic status on their choice of bone marrow transplantation donor cells and their chance of receiving genetically similar (allogeneic) bone marrow cells versus cells that are not genetically similar (allograft).

Description:

Primary Objectives To prospectively evaluate graft options and choice of donor by patient ancestry and SES for allograft candidates at MDACC.

Secondary Objectives

• To prospectively evaluate time to transplant for allograft candidates at MDACC.

• To evaluate treatment-related mortality for allograft candidates at MDACC.

• To assess overall survival for allograft candidates at MDACC.

• To prospectively evaluate receipt of preferred unrelated donor for allograft recipients at MDACC.

• To evaluate receipt of an optimal graft for allograft recipients at MDACC.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 1200
• Est. completion date: June 1, 2029
• Est. primary completion date: June 1, 2027
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. = 18 years of age.

2. Candidate for allogeneic transplantation

Exclusion Criteria:

1) Allogeneic stem cell transplantation not medically indicated.

Related Conditions & MeSH terms

• Allogeneic Transplantation

Intervention

Behavioral:
• Patient Ancestry Questionnaires
Participants will be asked to complete a demographics and ancestry questionnaire at the baseline visit before you and your doctor select bone marrow donation candidates.

Locations

Country	Name	City	State
United States	MD Anderson Cancer Center	Houston	Texas

Sponsors (1)

Lead Sponsor	Collaborator
M.D. Anderson Cancer Center

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Patient Ancestry Questionnaire		Through study completion; an average of 1 year.

External Links

•   MD Anderson Cancer Center