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NCT05848986 Clinical Trial

Study if the Presence of Functional FcERI/RII on the Surface of Human Blood Platelet

Allergy Clinical Trial

— FERIplaq  

Official title:
Study if the Presence of Functional FcERI/RII on the Surface of Human Blood Platelet

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05848986
Other study ID # 8947
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date June 1, 2023
Est. completion date April 1, 2025

Study information
Verified date March 2023
Source University Hospital, Strasbourg, France
Contact CHARLES AMBROISE TACQUARD, MD
Phone 03 69 55 16 08
Email charlesambroise.tacquard@chru-strasbourg.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Anaphylactic shock is the most severe expression of immediate hypersensitivity reactions. The mechanisms leading to these reactions are still poorly understood and may involve platelets, especially in the most severe forms. The IgE ( ImmunoglobulineE)-mediated mechanism, involving the FcERI(the high-affinity receptor for the Fc region of immunoglobulin E (IgE) receptor present on the surface of mast cells and basophilic cells, is the most common mechanism. The receptors FcERI and FcERII are also described as being present on the surface of blood platelets, which would imply their activation along with the other cells involved. However, studies showing the presence of the FcERI/RII receptors on blood platelets suffer from many biases. The main objective of the research is to study whether the FcERI/RII receptors are present and functional on the surface of blood platelets from allergic patients.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 20
Est. completion date April 1, 2025
Est. primary completion date June 1, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age > 18 years-old - With a protein/drug allergy (hymenoptera, arachide, amoxicillin) - Confirmed by skin tests and/or challenge test - With specific IgEs Exclusion Criteria: - Patients who refuse to participate to this study - Patients unable to consent

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Flow cytometry
Analysis of blood samples from a health sample's allergic patients and analysis with flow cytometry

Locations
Country Name City State
France Les Hôpitaux Universitaires Strasbourg

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Strasbourg, France

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary Presence of functionnal FcERI/RII receptors on the surface of blood platelets from allergic patients After confirmation of the allergy by a well conducted allergy workup 1 day
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