Allergy Clinical Trial
Official title:
A Prospective, Open Label, Single-center Study of the Long-term Prognosis of Moderate to Severe Bronchial Hyperresponsiveness (BHR) in Asthmatic Preschool Children.
The aim of investigator´s clinical trial is to investigate 52 patients aged three to five years with viral-induced asthma and 52 patients aged three to five years with allergic asthma. Over a time-span of 5 years the investigators will explore lung function and bronchial responsiveness. The investigators plan to evaluate long-term clinical history of moderate to severe bronchial hyperresponsiveness in preschool children with asthma. Therefore factors like atopy in children, parental atopy and bronchial hyperresponsiveness will be explored.
A positive family history with prevalence of atopy, eczema, wheezing are well-known factors
predicting asthma. Caudri et al. found more important predictors like perinatal
transmission, parental use of inhalative medications and wheezing/dyspnea out of viral
infections(5). Measurement of BHR in children was in most studies a second outcome
parameter.
Four visits will be performed, baseline and after 1, 3, and 5 years. At visit 1 the
investigators will characterize all patients by a ISAAC survey. At each visit in children a
methacholine challenge, a skin Prick test, eNO, RAST and total IgE will be performed. At
visit 3 and 4 sputum will be induced. In parents only at the first visit a methacholine
challenge will be performed. A genetic identification of ADAM33 gene from EDTA blood shall
be provided. ADAMs are multidomain proteins with a metalloprotease domain, associated with
airway remodelling. Visits should be kept in a time interval without asthma therapy and
respiratory infection.
To examine the feasibility of methacholine challenges in preschool children data measured in
2006 will be analysed.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT02032056 -
Effect of Probiotics in Reducing Infections and Allergies in Young Children During the Complementary Feeding Period
|
N/A | |
| Completed |
NCT01842711 -
Cumulative Irritation Patch Test
|
N/A | |
| Completed |
NCT01633840 -
New Validated Recipes for Double-blind Placebo-controlled Low Dose Food Challenges
|
N/A | |
| Completed |
NCT00997971 -
Growth, Tolerance in Healthy Infants Fed a Partially Hydrolyzed Rice Protein
|
Phase 3 | |
| Completed |
NCT00554983 -
Efficacy and Safety From a Recombinant Folding Variant of Bet v 1
|
Phase 3 | |
| Completed |
NCT00331929 -
Respiratory Health Study of Children in Kiryat Tivon
|
N/A | |
| Completed |
NCT00232518 -
Randomised Controlled Clinical Trials of the Effect of Therapeutic Hookworm Infection in Allergic Rhinoconjunctivitis
|
N/A | |
| Completed |
NCT00220753 -
Air Cleaners for Children and Adolescents With Asthma and Dog Allergy
|
N/A | |
| Completed |
NCT04126096 -
Negative Predictive Value and NIC of Beta-Lactam Antibiotics.
|
N/A | |
| Completed |
NCT04046731 -
Neuromuscular Blocking Agents Utilized During Perioperative Hypersensitivity Evaluation
|
N/A | |
| Completed |
NCT04004351 -
Treatment Modalities in Children and Adolescents Suffering From HDM-induced Allergic Rhinitis and/or Asthma
|
||
| Not yet recruiting |
NCT05997784 -
Study of Indoor Air Pollutants and Their Impact in Childhood Health and Wellbeing
|
||
| Completed |
NCT04418999 -
Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus
|
Early Phase 1 | |
| Completed |
NCT04186949 -
Early Origins of Allergy and Asthma
|
||
| Completed |
NCT02127801 -
Single Ascending-dose Study of the Efficacy, Safety, Tolerability, and Pharmacokinetics of REGN1908-1909 in Allergic, Adult Participants
|
Phase 1 | |
| Enrolling by invitation |
NCT05011071 -
The Alberta BLOOM Premature Child Study
|
||
| Not yet recruiting |
NCT06330974 -
Allergy, Asthma, and Atopic Eczema in Finland
|
||
| Terminated |
NCT02601690 -
Observational Analysis of T Cell Responses to SPIREs for Multiple Allergens in Subjects With Allergy in North America
|
||
| Completed |
NCT02306473 -
The Leaky Lung Test
|
Early Phase 1 | |
| Completed |
NCT02596321 -
A Study Investigating the Immunologic Effects and Safety of 60-day Treatment of the ALK HDM Tablets in Adult Subjects With HDM-Induced Allergic Rhinitis and/or Atopic Asthma
|
Phase 3 |