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Assessment of Suppression of Cutaneous Allergic Responses and Pruritis by Topical Minocycline — GINA3  

Asthma Clinical Trial

Official title:
Assessment of Suppression of Cutaneous Allergic Responses and Pruritis by Topical Minocycline

Clinical Trial Summary

Adults with known respiratory allergy/asthma with known skin test sensitization will undergo repeat skin prick testing at 4 areas of both arms (bilateral forearms, bilateral upper arms). Each site will be challenged with up to three known allergens, saline and histamine controls. Mean wheal diameter after 20 minutes challenge will be determined. This is followed by placement of minocycline cream (0%, 1%, 2%, 3%), placed in randomized fashion at each of 1 of 4 skin test sites. Measurement of subsequent wheal diameter will be done at 30 minutes, 60 minutes and 24 hours.

Clinical Trial Description

Adults with known respiratory allergy/asthma with known skin test sensitization will undergo repeat skin prick testing at 4 areas of both arms (bilateral forearms, bilateral upper arms). Each site will be challenged with up to three known allergens, saline and histamine controls. Mean wheal diameter after 20 minutes challenge will be determined. This is followed by placement of minocycline cream (0%, 1%, 2%, 3%), placed in randomized fashion at each of 1 of 4 skin test sites. Measurement of subsequent wheal diameter will be done at 30 minutes, 60 minutes and 24 hours. In addition, itch assessment at each site will be done at baseline, 30 minutes, 60 minutes and 24 hours using VAS and questionnaire. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04202263
Study type Interventional
Source State University of New York - Downstate Medical Center
Contact Rauno O Joks
Phone 7182701569
Email rauno.joks@downstate.edu
Status Recruiting
Phase Phase 2
Start date September 26, 2019
Completion date September 25, 2023
View Details
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