Effect of a Probiotic on Grass Pollen Allergic Rhinitis Subjects

Status Completed

Clinical Trial Summary

Various studies in animals and humans have shown a potential beneficial effect of probiotics consumption on allergy. However, few studies exist that document their efficacy for upper airways allergies such as allergic rhinitis. The objective of this study is to investigate the effect of short-term oral administration of a Lactobacillus paracasei on a nasal provocation test (NPT) with grass pollen, performed out of pollen season. Adult volunteers with allergic rhinitis are enrolled in a randomized, double-blind, placebo-controlled study, based on two 4-weeks cross-over periods of product consumption (probiotic-fermented milk versus placebo), separated by a washout period of 6-8 weeks. Objective and subjective clinical parameters of NPT as well as systemic and nasal immunological parameters are compared between the two treatment periods.

Clinical Trial Description

n/a

Study Design

Intervention Model: Crossover Assignment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01150253
Study type	Interventional
Source	Nestlé
Contact
Status	Completed
Phase	N/A
Start date	August 2006
Completion date	March 2007

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