Allergic Rhinitis Clinical Trial
Official title:
Analysis of Immunological Reactions to Pollen-Related Foods in Birch Pollen-Allergic Patients
A high number of birch pollen-allergic individuals develop hypersensitivity reactions to
certain foods, e.g. apples. This food allergy is due to immunological cross-reactivity.
Birch pollen-related foods contain proteins, e.g. Mal d 1 in apple, that are structurally
related with the major birch pollen allergen, Bet v 1. Hence IgE antibodies and T
lymphocytes specific for Bet v 1 recognize these food proteins which results in activation
of the immune system and, consequently, in clinical symptoms.
In the present study the investigators intend to investigate if and how the consumption of
birch pollen-related food allergens affects birch pollen allergy. In other words, the
investigators are interested to analyse whether Bet v 1-related food allergens activate Bet
v 1-specific memory cells and thus, contribute to the maintenance of the pollen allergy
outside the pollen season. Data obtained in this study will help to clarify the
immunological and clinical role of cross-reactivity between pollen and food allergies and
will reveal whether avoidance of such foods should be recommended for the patients. Finally,
novel approaches for diagnosis and therapy of pollen-related food allergens can be
developed.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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