The Development of Allergic Rhinitis in Children Previously Diagnosed as Nonallergic Rhinitis

Allergic Rhinitis (Disorder) Clinical Trial

Official title:

The Development of Allergic Rhinitis in Children Previously Diagnosed as Nonallergic Rhinitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01068808
• Other study ID #: 640/2552(EC4)
• Status: Completed
• Phase: N/A
• First received: February 12, 2010
• Last updated: February 18, 2013
• Start date: January 2010
• Est. completion date: August 2012

Study information

• Verified date: February 2013
• Source: Mahidol University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Thailand: Ethical Committee
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to evaluate development of allergic rhinitis in children with nonallergic rhinitis.

Description:

Rhinitis is a common condition associated with significant effects on quality of life. Rhinitis may be divided into two groups, those with concurrent allergy (allergic rhinitis, AR) and those without allergy but who still suffer from nasal symptoms (nonallergic rhinitis, NAR).

Evidence indicated that adult with NAR can have de novo sensitization to aeroallergen (24%), suggesting that patients with NAR might evolve to AR. Thus the purpose of this study is to evaluate development of allergic rhinitis in children with nonallergic rhinitis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 175
• Est. completion date: August 2012
• Est. primary completion date: June 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 1 Year to 15 Years

Eligibility

Inclusion Criteria:

• Children between the age of 1 year and 15 years with the diagnosis of nonallergic rhinitis who are attending the pediatric allergy clinic during Jan 2005 - Dec 2007.

Exclusion Criteria:

• Patients who have allergic rhinitis and underlying disease eg.chronic renal disease, liver disease, heart disease, cancer.

Study Design

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Allergic Rhinitis (Disorder)
• Common Cold
• Rhinitis

Intervention

Procedure:
• skin prick test
skin prick test to aeroallergen

Locations

Country	Name	City	State
Thailand	Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University	Bangkok

Sponsors (1)

Lead Sponsor	Collaborator
Mahidol University

Country where clinical trial is conducted

Thailand, 

References & Publications (1)

Veskitkul J, Vichyanond P, Visitsunthorn N, Jirapongsananuruk O. The development of allergic rhinitis in children previously diagnosed as nonallergic rhinitis. Am J Rhinol Allergy. 2013 Jan;27(1):43-7. doi: 10.2500/ajra.2013.27.3839. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To evaluate the development of AR in children who were previously diagnosed with NAR		24 months	Yes
Secondary	To determine the persistence and severity of the symptoms, new comorbidities and triggering factors in children with nonallergic rhinitis		24 months	Yes