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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05185362
Other study ID # RECHMPL21_0726
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date November 1, 2021
Est. completion date April 1, 2022

Study information

Verified date December 2021
Source University Hospital, Montpellier
Contact Davide CAIMMI, MD
Phone 467336112
Email davide.caimmi@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

IgE-mediated food allergy can manifest with reactions ranging from hives to anaphylactic shock. The diagnosis is based on the confirmation of sensitization to the food allergen by skin tests (prick) and the determination of specific IgE directed against the food source and molecular allergens. The gold standard remains the oral provocation test, which is performed in a hospital environment. Once the diagnosis is made, an elimination diet is still considered as the cornerstone of treatment for most food allergies. While some allergies, such as cow's milk or egg, tend to resolve spontaneously, others, such as allergy to pecan nuts, show a tendency to be persistent. In addition, pecan allergy is often characterized by potentially serious clinical reactions, compared to other foods, which can even be life threatening. In our clinical practice, the investigators found that patients with allergies to pecan nuts often present with severe hypersensitivity reactions when challenged orally to this food. Beyond this information, there are few studies regarding pecans. The investigators decided to retrospectively evaluate the results of oral food challenge and of the allergy work-up in our patients sensitized and allergic to pecan nuts, to better understand the current epidemiology of such food allergy.


Recruitment information / eligibility

Status Recruiting
Enrollment 50
Est. completion date April 1, 2022
Est. primary completion date January 1, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 5 Years to 70 Years
Eligibility Inclusion criteria: - Patients assessed for pecan allergy, through oral food challenge, from January 2000 to december 2021, at the University Hospital of Montpellier - Patients with a positive skin prick test and/or positive specific IgE to pecan nut Exclusion criteria: - Patients not affiliated to French Social Security - Patients not capable of understanding French - Patients sensitized to pecan nut, who did not perform an oral food challenge to this food allergen

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
France Uhmontpellier Montpellier

Sponsors (1)

Lead Sponsor Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary Prevalence of challenge-proven pecan allergy Prevalence of challenge-proven pecan allergy in sensitized patients day 1
Secondary Epidemiological characteristics of pecan allergic patient Epidemiological characteristics of pecan allergic patient(cypress pollen-induced allergic rhinitis or food allergy to peach) day 1
Secondary cut-off of specific IgE cut-off of specific IgE and of results of prick test to predict pecan allergy in sensitized and allergic patients day 1
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