Allergic Contact Dermatitis Clinical Trial
Official title:
Alteration of the microRNA-126 Expression: a Possible Mechanism in Allergic Contact Dermatitis to Nickel
Background. Allergic Contact Dermatitis (ACD) is an inflammatory skin disease mediated by
direct contact with allergens as nickel, the most common allergen, that may be related with
epigenetic changes.
Objective. Evaluate the miR-126 expression and its target VCAM-1, in the skin of patients
with ACD to nickel.
Methods. Fifteen patients with positive patch test to nickel were included, and the
expression of miR-126 and VCAM-1 was evaluated by RT-qPCR.
Patients that went to the dermatology and outpatient department of the Central Hospital "Dr. Ignacio Morones Prieto ", with a suspected diagnosis of nickel allergic contact dermatitis, were invited to participate in this study. Later, the objective and methodology of the study were explained to them, as well as the advantages of participating and the possible undesirable effects. All patients signed the informed consent previous perfom the medical history. After, the epicutaneous patch test was performed, and patients were divided according to the result them. Finally, under local anesthesia, two 3-mm punch biopsies, from lesional (positive parch test site) and adjacent non lesional skin, 10 cm apart, were performed. Tissues for reverse transcriptase real-time polymerase chain reaction (RT-qPCR) analyses were stored frozen in sterile tubes at 80ºC until processing ;
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