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NCT03307278 Clinical Trial

House Dust Mite Induced Inflammasome Activation on Corticosteroid Resistance

Allergic Asthma Clinical Trial

Official title:
Effects and Mechanism of House Dust Mite Induced Inflammasome Activation on Corticosteroid Resistance

Clinical Trial Details — Status: Withdrawn

Administrative data
NCT number NCT03307278
Other study ID # CMUH106-REC3-115
Secondary ID
Status Withdrawn
Phase N/A
First received
Last updated
Start date November 30, 2017
Est. completion date September 6, 2018

Study information
Verified date July 2021
Source China Medical University Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

In this project, PBMCs will be isolated from HDM allergic and non allergic patient and then stimulated with HDM crude extract. The expression of inflammasome and the correlation of inflammasome activation and steroid resistance will be investigated.

Recruitment information / eligibility
Status Withdrawn
Enrollment 0
Est. completion date September 6, 2018
Est. primary completion date September 6, 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years to 70 Years
Eligibility Inclusion Criteria: - HDM allergic and non allergic subjects Exclusion Criteria: - Pregnant subject, cancer

Study Design

Related Conditions & MeSH terms

Intervention

Biological:
• House dust mite
As a stimulant to induce inflammasome activation

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
China Medical University Hospital

Outcome
Type Measure Description Time frame Safety issue
Primary inflammasome activation by HDM The expression of NLRP3 in PBMCs will be measured by western blot after HDM stimulation. 6 hours
Primary Steroid receptor phosphorylation by HDM The expression of steroid receptor will be detected by western blot and real-time PCR after HDM stimulation. 6 hours
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