Allergic Asthma Clinical Trial
Official title:
Repeatability of a Single Concentration and Single-step Bronchial Allergen Challenge With Grass Pollen
The study is meant to establish a one-step challenge with grass-pollen in patients sensitized for grass-pollen. Therefore the investigators compare a multi-step challenge with grass-pollen with an one-step challenge in order to survey the repeatability and safety.
Background:
Specific provocation with inhaled allergens is an established tool in clinical practice and
research, supporting the understanding of pathophysiology of allergic asthma, and analysing
the efficacy of new therapies. This study examines the repeatability of a bolus-dose
inhalative allergen challenge with grass pollen.
Method:
Forty grass pollen allergics should undergo an incremental-dose grass pollen challenge to
calculate their PD20-dose. This calculated dose will be applicated twice to analyse the
repeatability of the bolus dose challenge. Before and twenty-four hours after the
provocation, exhaled nitric oxid (FeNO) will be determined as a marker of bronchial
inflammation.
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Observational Model: Cohort, Time Perspective: Cross-Sectional
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