All Tumor Types Clinical Trial
— SPECTAOfficial title:
SPECTA: Screening Cancer Patients for Efficient Clinical Trial Access
| NCT number | NCT02834884 |
| Other study ID # | EORTC-1553 |
| Secondary ID | |
| Status | Recruiting |
| Phase | |
| First received | |
| Last updated | |
| Start date | May 3, 2017 |
| Est. completion date | March 2026 |
SPECTA is a quality assured platform for collecting clinicopathologically annotated biological material, imaging data, operative images, environmental assessment, questionnaires as well as patient-reported outcomes from cancer patients to support biospecimen-based translational research and clinical cancer research, including biomarker discovery to improve the understanding of tumor biology and cancer patients care.
| Status | Recruiting |
| Enrollment | 4975 |
| Est. completion date | March 2026 |
| Est. primary completion date | March 2026 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 12 Years and older |
| Eligibility | - Patients with pathologically confirmed selected tumor types (at site or centrally); - Mandatory availability of adequate human biological material (HBM); - Centrally performed confirmation of HBM adequacy in terms of quality and quantity for SPECTA downstream project requirements; - Age = 12 years; - Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; - Written informed consent according to applicable legal and ethical requirements; |
| Country | Name | City | State |
|---|---|---|---|
| Austria | Medical University Vienna - General Hospital AKH | Vienna | |
| Belgium | Onze Lieve Vrouw Ziekenhuis | Aalst | |
| Belgium | ZNA Middelheim | Antwerp | |
| Belgium | Cliniques Universitaires Saint-Luc | Brussels | |
| Belgium | Hopitaux Universitaires - Institut Jules Bordet | Brussels | |
| Belgium | Universitair Ziekenhuis Brussel | Brussels | |
| Belgium | Universitair Ziekenhuis Gent | Gent | |
| Belgium | U.Z. Leuven - Campus Gasthuisberg | Leuven | |
| Belgium | C.H.U. Sart-Tilman | Liège | |
| Belgium | Centre Hospitalier Regional De La Citadelle | Liège | |
| Belgium | CHU Site Sainte-Elisabeth-UCL Namur | Namur | |
| Belgium | AZ Turnhout - Campus Sint Elisabeth | Turnhout | |
| Belgium | CHU Mont Godinne - UCL Namur | Yvoir | |
| Croatia | University Hospital Centre Zagreb | Zagreb | |
| Cyprus | Bank Of Cyprus Oncology Centre | Stróvolos | |
| Czechia | University Hospital Motol | Prague | |
| Estonia | North Estonia Medical Centre - Mustamäe unit | Tallinn | |
| France | Institut de Cancerologie de l'Ouest (ICO) - Centre Paul Papin | Angers | |
| France | Centre Hospitalier Avignon | Avignon | |
| France | CHRU de Besancon - Hopital Jean Minjoz | Besancon | |
| France | Centre de Radiotherapie Pierre Curie | Beuvry | |
| France | CHU de Bordeaux - Groupe Hospitalier Saint-Andre - Hopital Saint-Andre | Bordeaux | |
| France | Institut Bergonie | Bordeaux | |
| France | CHU de Lyon - Hopital Louis Pradel | Bron | |
| France | CHU Lyon - Hopital neurologique Pierre Wertheimer | Bron | |
| France | Centre Hopitalier Intercommunal De Creteil | Creteil | |
| France | Centre Georges-Francois-Leclerc | Dijon | |
| France | CHU de Grenoble - La Tronche - Hôpital A. Michallon | Grenoble | |
| France | Centre Hospitalier Departemental Vendee | La Roche Sur Yon | |
| France | Centre Oscar Lambret | Lille | |
| France | CHRU de Lille | Lille | |
| France | Centre Léon Berard | Lyon | |
| France | CHU de Lyon - Hopital Edouard Herriot | Lyon | |
| France | CHU de Lyon - Hopital Lyon Sud | Lyon | |
| France | Assistance Publique - Hopitaux de Marseille - Hopital Nord | Marseille | |
| France | Centre Hospitalier D'Annecy | Metz-Tessy | |
| France | CHU Montpellier-Hopital Arnaud De Villeneuve | Montpellier | |
| France | Institut du Cancer de Montpellier | Montpellier Cedex 5 | |
| France | Centre Hospitalier Des Pays De Morlaix | Morlaix | |
| France | Centre d'Oncologie de Gentilly | Nancy | |
| France | CHU de Nice - Hopital De L'Archet | Nice | |
| France | Assistance Publique - Hopitaux de Paris - Hopital Saint Antoine | Paris | |
| France | Assistance Publique - Hopitaux de Paris - La Pitie Salpetriere | Paris | |
| France | Assitance Publique - Hopitaux de Paris - Hopital Saint-Louis | Paris | |
| France | Groupe Hospitalier Paris Saint-Joseph - Hopital Saint Joseph | Paris | |
| France | Centre Eugene Marquis | Rennes | |
| France | Clinique Mutualiste de l'Estuaire - Centre d'oncologie | Saint Nazaire | |
| France | Institut de Cancerologie de l'Ouest (ICO) - Centre Rene Gauducheau | Saint-Herblain | |
| France | Institut de Cancerologie de la Loire Lucien Neuwirth | Saint-Priest-en-Jarez | |
| France | Institut de Cancerologie Strasbourg Europe (formar Paul Strauss) | Strasbourg | |
| France | CHU Toulouse - Hopital Larrey | Toulouse | |
| France | Gustave Roussy | Villejuif | |
| Germany | Charite - Universitaetsmedizin Berlin - Campus Virchow-Klinikum | Berlin | |
| Germany | Universitaetsklinikum Carl Gustav Carus | Dresden | |
| Germany | Universitaetsklinikum Jena | Jena | |
| Germany | Onkologie UnterEms, Leer-Papenburg-Emden | Leer | |
| Greece | Athens University - Attikon University General Hospital | Athens | |
| Greece | Hygeia Hospital | Athens | |
| Greece | NIMTS - Veterans Administration Hospital | Athens | |
| Greece | Ioannina University Hospital | Ioánnina | |
| Italy | Ospedale Civile Santi Antonio e Biagio e Cesare Arrigo | Alessandria | |
| Italy | Alma Mater Studiorium Universita di Bologna - Loc. Ospedala Sant'Orsolo | Bologna | |
| Italy | Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia | Brescia | |
| Italy | Azienda Istituti Ospitalieri di Cremona | Cremona | |
| Italy | IRCCS Azienda Ospedaliera Universitaria San Martino "IST" Istituto Nazionale per la Ricerca sul Cancro | Genova | |
| Italy | Azienda Unita Locale Socio-Sanitaria N. 9-Mater Salutis Hospital | Legnago | |
| Italy | IRCCS - Istituto Neurologico Carlo Besta | Milano | |
| Italy | Ospedale del Mare | Napoli | |
| Italy | Universita Di Torino - Ospedale S. Luigi Gonzaga | Orbassano | |
| Italy | IRCCS - Istituto Oncologico Veneto | Padova | |
| Italy | Istituti Clinici Scientifici Maugeri | Pavia | |
| Italy | Regina Elena National Cancer Center | Roma | |
| Italy | Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale Molinette | Torino | |
| Italy | Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale San Giovanni - Dipartimento Neuroscienze | Torino | |
| Italy | Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale Sant'Anna | Torino | |
| Lithuania | Lithuanian Oncology Center-Nat. Cancer Inst | Vilnius | |
| Netherlands | Amsterdam UMC - Locatie AMC | Amsterdam | |
| Netherlands | The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis | Amsterdam | |
| Netherlands | University Medical Center Groningen | Groningen | |
| Netherlands | Academisch Ziekenhuis Maastricht | Maastricht | |
| Netherlands | Radboud University Medical Center Nijmegen | Nijmegen | |
| Poland | Medical University Of Gdansk | Gdansk | |
| Poland | Maria S. Curie Memorial Institute-Gliwice Branche | Gliwice | |
| Poland | The Great Poland Cancer Centre | Poznan | |
| Poland | Maria Sklodowska-Curie Memorial Cancer Centre | Warsaw | |
| Portugal | Centro Hospitalar de Lisboa Ocidental- San Francisco Xavier Hospital | Lisboa | |
| Portugal | Hospital CUF Descobertas | Lisboa | |
| Portugal | Hospital CUF Tejo | Lisboa | |
| Portugal | Instituto Portugues de Oncologia de Lisboa Francisco Gentil - EPE | Lisboa | |
| Portugal | Centro Hospitalar do Porto- Hospital de Santo Antonio | Porto | |
| Portugal | Instituto Portugues de Oncologia do Porto | Porto | |
| Portugal | Cen.Hospitalar Vila Nova Gaia | Vila Nova De Gaia | |
| Romania | Medisprof Cancer Center srl | Cluj | Cluj Napoca |
| Serbia | University Clinic Centre Serbia - Pulmonoloy clinic | Belgrade | |
| Serbia | University Clinical Center of Serbia - Clinic for ENT and MFH | Belgrade | |
| Slovenia | University Clinic Golnik | Golnik | |
| Slovenia | University Medical Center Maribor | Maribor | |
| Spain | Hospital Clinic Universitari de Barcelona | Barcelona | |
| Spain | Hospital De La Santa Creu I Sant Pau | Barcelona | |
| Spain | Vall d'Hebron Institut d'Oncologia | Barcelona | |
| Spain | Hospital General Universitario De Elche | Elche | |
| Spain | ICO Girona - Hospital Doctor Josep Trueta (Institut Catala D'Oncologia) | Girona | |
| Spain | ICO L'Hospitalet- Hospital Universitari de Bellvitge | L'Hospitalet De Llobregat | |
| Spain | Hospital Infantil Universitario Nino Jesus | Madrid | |
| Spain | Hospital Universitario 12 de Octubre | Madrid | |
| Spain | Hospital Universitario Infanta Leonor | Madrid | |
| Spain | Hospital Universitario QuironSalud | Madrid | |
| Spain | Hospital Universitario Ramon y Cajal | Madrid | |
| Spain | Hospital Universitario San Carlos | Madrid | |
| Spain | Hospital Universitario Virgen De La Victoria | Malaga | |
| Spain | Hospital Clinico Universitario De Valencia | Valencia | |
| Spain | Hospital Clinico Universitaro De Valladolid | Valladolid | |
| Switzerland | Hirslanden Klinik-Tumor Zentrum Aarau | Aarau | |
| Switzerland | Kantonsspital St Gallen | Saint Gallen | |
| Switzerland | UniversitaetsSpital Zurich | Zurich | |
| Switzerland | UniversitaetsSpital Zurich - Neurology Clinic | Zurich | |
| United Kingdom | Royal Orthopaedics Hospital, NHS Trust | Birmingham | |
| United Kingdom | University Hospitals Birmingham NHS Foundation Trust (UHB) - UHB-Queen Elisabeth Medical Centre | Birmingham | |
| United Kingdom | Betsi Cadwaladr University Health Board - Glan Clwyd District General Hospital | Bodelwyddan | Denbighshire |
| United Kingdom | Cambridge University Hospital NHS - Addenbrookes Hospital | Cambridge | |
| United Kingdom | Velindre NHS Trust - Velindre Cancer Centre | Cardiff | |
| United Kingdom | University Hospitals Coventry and Warwickshire NHS Trust - University Hospital | Coventry | |
| United Kingdom | NHS Lothian - Western General Hospital | Edinburgh | |
| United Kingdom | NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital | Glasgow | |
| United Kingdom | Hereford County Hospital | Hereford | |
| United Kingdom | Leeds Teaching Hospitals NHS Trust - St. James's University Hospital | Leeds | |
| United Kingdom | Royal Free Hospital | London | |
| United Kingdom | The Christie NHS Foundation Trust | Manchester |
| Lead Sponsor | Collaborator |
|---|---|
| European Organisation for Research and Treatment of Cancer - EORTC |
Austria, Belgium, Croatia, Cyprus, Czechia, Estonia, France, Germany, Greece, Italy, Lithuania, Netherlands, Poland, Portugal, Romania, Serbia, Slovenia, Spain, Switzerland, United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | To establish a quality assured platform to improve the understanding of tumor biology and cancer patients care | material (including imaging data) as well as patient-reported outcomes from patients with cancer diagnosis to support biospecimen-based translational research and biomarker discovery to improve the understanding of tumor biology and cancer patients care. | 5 years | |
| Secondary | To perform biospecimen and data based high quality research aiming to better understand the biology of cancer, and/or how it is currently managed and/or how to better diagnose and treat it in the future; | 5 years | ||
| Secondary | To investigate the molecular pathways related to the development of specific tumors from a biological point of view; | 5 years | ||
| Secondary | To investigate the effect of cancer treatment on the tumor, microenvironment and patients globally; | 5 years | ||
| Secondary | To collect large series of homogeneous clinical data to analyse the disease course and treatment performed; | 5 years | ||
| Secondary | To investigate the prevalence and validate the prognostic or predictive value of novel biomarkers in cancers; | 5 years | ||
| Secondary | To perform biospecimen and data based high quality research aiming to facilitate the discovery of new test for tumor biomarkers or facilitate the establishment of validated tests for tumor biomarkers; | 5 years | ||
| Secondary | To identify patients with molecular alterations in their tumor that can be matched to biomarker-driven clinical trials, to facilitate enrollment of cancer patients in biomarker-driven clinical trials. | 5 years |