Alcoholism Clinical Trial
Official title:
PTSD, AUD, and Interpersonal Conflict: Within-person Associations
The present study seeks to increase understanding of Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD) among veterans, an important public health concern. We will study the effects of regulatory deficits and sleep disturbance on the dynamic course of PTSD and AUD. The study will investigate whether a short, computerized training in the laboratory will alter maladaptive response biases and reduce associations between sleep disturbance, affect and behavioral dysregulation, AUD symptoms, and PTSD symptoms in the real world.
Status | Recruiting |
Enrollment | 250 |
Est. completion date | April 30, 2025 |
Est. primary completion date | April 30, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility | Inclusion Criteria: - OIF/OEF/OND veterans - At risk for PTSD (i.e., PCL-5 =33) and/or AUD (i.e., AUDIT = 7 (women) = 8 (men)) Exclusion Criteria: - Psychosis or severe Alcohol Use Disorder that contraindicates participation (based on interview) - Active suicidal or homicidal ideation that contraindicates participation (based on interview) - [exclusion criteria removed 6/2022] - Severe risk for sleep apnea (a positive score in three categories of the Berlin Questionnaire), or reported treatment for sleep apnea |
Country | Name | City | State |
---|---|---|---|
United States | Bay Pines VA Health Care System | Bay Pines | Florida |
United States | Sioux Falls VA Health Care System | Sioux Falls | South Dakota |
United States | The University of South Dakota | Vermillion | South Dakota |
Lead Sponsor | Collaborator |
---|---|
University of South Dakota | Bay Pines VA Healthcare System, National Institute of Mental Health (NIMH), Sioux Falls VA Health Care System |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Rate of Alcohol Use Disorder Symptoms | These are experience sampling items derived from Diagnostic and Statistical Manual of Mental Disorders (DSM-5). | 2 years | |
Primary | Rate of PTSD Symptoms | These are experience sampling items derived from the PTSD Checklist from DSM-5 (PCL-5). | 2 years |
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