Alcoholism Clinical Trial
Official title:
A Pilot Study of Sertraline Plus Relapse Prevention Therapy (RP) for the Treatment of Pathological Gambling With Comorbid Abuse or Dependence
Pathological gamblers often are also dependent on alcohol and clinically depressed. Sertraline (Zoloft) is currently used to treat depression, panic disorder, and obsessive-compulsive disorder. The purpose of this trial is to determine the effectiveness of sertraline used in combination with relapse prevention therapy in decreasing gambling behavior and alcohol consumption in individuals with a diagnosis of pathological gambling and alcohol abuse or dependence.
Alcohol abuse and depression commonly occur in conjunction with pathological gambling.
Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI) currently used to
treat depression, panic disorder, and obsessive-compulsive disorder. The purpose of this
trial is to determine the effectiveness of sertraline combined with relapse prevention
therapy in decreasing gambling behavior and alcohol abuse.
Participants in this 10-week trial will be randomly assigned to receive either relapse
prevention (RP) therapy and sertraline or RP therapy and a placebo. Participants will begin
taking 25 mg of either sertraline or placebo in a single morning dose for one week. If, after
one week, participants do not show improvement, the dose will increase to 50 mg per day
during Week 2, and will increase by 50 mg per day every week thereafter to a maximal dose of
200 mg per day.
Weekly hour-long study visits will include a medication evaluation, RP therapy, and
questionnaires. In addition, evaluations at baseline, Week 5, and Week 10 will include
pathological gambling and depression ratings, urine drug screens, and biochemical measures of
alcohol consumption and liver function. All other weekly study visits will include evaluation
of side effects, an interview on alcohol use, measures related to obsessive-compulsive
drinking, and assessments of vital signs and concomitant medications.
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