Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease

Alcoholic Liver Disease Clinical Trial

Official title:

Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00610597
• Other study ID #: AL-ALD
• Secondary ID: AL-ALD
• Status: Completed
• Phase: N/A
• First received: January 28, 2008
• Last updated: January 28, 2008
• Start date: January 2005
• Est. completion date: January 2008

Study information

• Verified date: January 2008
• Source: Erasme University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Belgium: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Alcoholic liver disease is characterized by circulating T cell activation and liver T cell infiltration but their phenotype is poorly studied. The aim of the study is to test the hypothesis that the (CD4+ T cell secreting Interleukin-17) Th17 pathway is involved in alcoholic liver disease.

Description:

Consecutive patients undergoing transjugular liver biopsies for alcoholic liver disease or hepatitis C virus infection will be included in the study to measure plasma cytokines levels, peripheral blood mononuclear cells cytokine release and liver T cell infiltrates.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 49
• Est. completion date: January 2008
• Est. primary completion date: January 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Alcohol excess intake and suspected liver disease

• Alcohol excess intake and clinical liver cirrhosis

• chronic hepatitis C virus infection and suspected liver disease

• chronic hepatitis C virus infection and clinical liver cirrhosis

Exclusion Criteria:

• bacterial or fungal infection

• immunosuppressive treatment

• other causes of liver disease

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Alcoholic Liver Disease
• Chronic Hepatitis C Virus
• Hepatitis C
• Hepatitis C, Chronic
• Hepatitis, Chronic
• Liver Diseases
• Liver Diseases, Alcoholic

Locations

Country	Name	City	State
Belgium	Hopital Erasme - Dpt of Gastroenterology	Brussels

Sponsors (1)

Lead Sponsor	Collaborator
Erasme University Hospital

Country where clinical trial is conducted

Belgium,