Clinical Trials Logo

Clinical Trial Summary

The purpose of the study is to evaluate if the drug prazosin: - will decrease alcohol use in active duty members of the military who served in Iraq and/or Afghanistan and - determine if presence or absence of posttraumatic stress disorder affects treatment.


Clinical Trial Description

The proposed study is a 19-week, titration to stable dose, randomized, two-group parallel-design, double-blind, placebo-controlled trial to evaluate the efficacy of prazosin for decreasing alcohol use in 200 active duty Service Members who served in the conflicts in Iraq and/or Afghanistan who are receiving standard outpatient treatment for alcohol use disorders at Joint Base Lewis-McChord. Treatment groups will be stratified by presence or absence of posttraumatic stress disorder (PTSD) and by assignment to the 6-week or 12-week Army Substance Abuse Program. The hypotheses are that: 1) prazosin is more effective than placebo for alcohol use disorders in these Service Members; and 2) that prazosin effect size will be greater in Service Members with PTSD than without PTSD. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02226367
Study type Interventional
Source Seattle Institute for Biomedical and Clinical Research
Contact
Status Completed
Phase N/A
Start date January 2015
Completion date October 20, 2018

See also
  Status Clinical Trial Phase
Completed NCT02179749 - Mifepristone Treatment of Alcohol Use Disorder Phase 2
Completed NCT02113618 - Effect of Cognitive Training on Alcohol Use Outcomes N/A
Completed NCT01008280 - Baclofen to Reduce Alcohol Use in Veterans With HCV Phase 4
Active, not recruiting NCT02671019 - Effectiveness and Costs of Internet-based Treatment for Harmful Alcohol Use and Face-to-face Treatment in Addiction Care N/A
Completed NCT01751035 - Integrative Risk Reduction and Treatment for Teen Substance Use Problems and PTSD N/A
Active, not recruiting NCT03695653 - Messaging Interventions to Reduce Alcohol Problems Project N/A
Completed NCT02298751 - Exposure Therapy as Aftercare for Alcohol Use Disorder N/A
Completed NCT01642381 - Component Analysis for Motivational Interviewing N/A
Terminated NCT01566370 - Zonisamide for Heavy Drinkers With Bipolar Disorder Phase 2
Completed NCT02384278 - Internet Based Cognitive Behavior Treatment for Alcohol Problems N/A
Completed NCT02511808 - Adaptive Interventions for Problem Drinkers N/A
Completed NCT01613014 - ABT-436 for Alcohol Dependence Phase 2
Completed NCT02905162 - Understanding Longitudinal Clinical Outcomes and Post-release Retention in Care Among HIV-infected Prisoners in Lusaka, Zambia
Completed NCT02808468 - Brief Restructuring Intervention Following Trauma Exposure N/A
Completed NCT01692054 - Risk and Protective Factors of Children and Adolescents Who Were Hospitalized Due to Alcohol Intoxication N/A
Completed NCT02500602 - CAP: Doxazosin in the Treatment of Co-Occurring PTSD and Alcohol Use Disorders Phase 2
Active, not recruiting NCT02713217 - Implementing a Blended Care Model That Integrates Mental Healthcare and Primary Care Using Telemedicine and Care Management for Patients With Depression or Alcohol Use Disorder in Small Primary Care Clinics
Recruiting NCT02465177 - Tailoring Screening, Brief Intervention, and Referral to Treatment for Medical ICU Survivors
Completed NCT02193256 - Varenicline + Prazosin for Heavy Drinking Smokers Early Phase 1
Completed NCT01172210 - Examining Common Substrates of Eating and Alcohol Use Disorders N/A