Attentional Control Training for Treating Alcohol Use Disorder

Status Not yet recruiting

Clinical Trial Summary

Background: There is consistent evidence that community and clinical samples of individuals with an alcohol use disorder (AUD) have attentional biases toward alcohol cues. The alcohol attentional control training program (AACTP) has shown promise for retraining these biases and decreasing alcohol consumption in community samples of excessive drinkers. However, there is a lack of evidence regarding the effectiveness of ACTP in clinical AUD samples. The main aim of the present study is to investigate whether primary pharmacological and psychological, evidence-based alcohol treatment can be enhanced by the addition of a gamified AACTP smartphone application for patients with an AUD. Design and methods: The study will be implemented as a randomized controlled trial. A total of 317 consecutively enrolled patients with AUD will be recruited from alcohol outpatient clinics in Denmark. Patients will be randomized to one of three groups upon initiation of primary alcohol treatment: Group A: a gamified AACTP smartphone application + treatment as usual (TAU); Group B: a gamified AACTP sham-control application + TAU; or Group C: only TAU. Treatment outcomes will be assessed at baseline, post-treatment, and at 3- and 6-month follow-ups. Repeated measures MANOVA will be used to compare the trajectories of the groups over time on alcohol attentional bias, alcohol craving, and drinking reductions. It is hypothesized that Group A will achieve better treatment outcomes than either Group B or Group C. Perspectives: Because attentional bias for alcohol cues is proportional to the amount of alcohol consumed, and these biases are not addressed within current evidence-based treatment programs, this study is expected to provide new evidence regarding the effectiveness of the gamified AACTP in a clinical population. Furthermore, due to promising results found using AACTP in community samples of excessive drinkers, there is a high probability that the AACTP treatment in this study will also be effective, thereby allowing AACTP to be readily implemented in clinical settings. Finally, it is expected that this study will increase the effectiveness of evidence-based AUD treatment and introduce a new, low-cost gamified treatment targeting patients with an AUD. Overall, this study is likely to have an impact at the scientific, clinical, and societal levels.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05102942
Study type	Interventional
Source	University of Southern Denmark
Contact	Angelina I Mellentin, Ph.D
Phone	+4550517901
Email	amellentin@health.sdu.dk
Status	Not yet recruiting
Phase	N/A
Start date	April 2022
Completion date	June 2024

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04927364` - Examining the Effectiveness of Deep TMS in Veterans With Alcohol Use Disorder	N/A
Active, not recruiting	`NCT04618653` - Comprehensive Process Model of AA-related Behavior Change
Recruiting	`NCT05471154` - Non-invasive Brain Stimulation of the Prefrontal Cortex in Substance Use Disorders	N/A
Completed	`NCT05021640` - Study of DCR-AUD in Healthy Volunteers	Phase 1
Not yet recruiting	`NCT05064228` - Mobile Rewarding Activity Centered Treatment	N/A
Completed	`NCT04958655` - Mental Imagery Intervention for Alcohol Craving	N/A
Completed	`NCT05252221` - Alcohol Telemedicine Consultation in Primary Care (ATC)	N/A
Completed	`NCT06108115` - Smartphone-Based Intervention for Sleep Disturbance in Individuals Recovering From Alcohol Use Disorder	N/A
Completed	`NCT04639895` - Cognitive Rehabilitation Through Personalized Virtual Reality and Paper-and-pencil Interventions in the Alcohol Use Disorder Treatment.	N/A
Completed	`NCT02911285` - NAC for Treating Comorbid PTSD and SUD	Phase 2
Recruiting	`NCT04598399` - Comparison of the Effectiveness of Two Psycho-physical Interventions: Mindfulness Based Relapse Prevention (MBRP) and Unguided Meditative Relaxation in Patients With Alcohol Use Disorder	N/A
Completed	`NCT04827056` - Effect of Sublingual Formulation of Dexmedetomidine HCl (BXCL501) - Alcohol Interaction Study	Phase 1
Completed	`NCT04974645` - Pilot: Digital Therapeutic vs Education for the Management of Problematic Substance Use	N/A
Recruiting	`NCT05992272` - Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer
Completed	`NCT04229095` - Medication Development in Alcoholism: Suvorexant Versus Placebo	Phase 2
Recruiting	`NCT05534568` - The Oklahoma Parent-Child Assistance Program	N/A
Completed	`NCT04925570` - The Anchor Study: Digitally Delivered Intervention for Reducing Problematic Substance Use	Phase 2
Active, not recruiting	`NCT05492942` - Records for Alcohol Care Enhancement	N/A
Recruiting	`NCT05015881` - Relationship Between Brain and Heart Glucose Metabolism in Alcohol Use Disorder	Phase 2/Phase 3
Active, not recruiting	`NCT05120856` - AAT-App Outpatient Trial	N/A