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Alcohol-Related Disorders clinical trials

View clinical trials related to Alcohol-Related Disorders.

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NCT ID: NCT04146636 Completed - NAFLD Clinical Trials

Screening in Primary Care of Advanced Liver Fibrosis in NAFLD and/or Alcoholic Patients (IMPROVE Study)

IMPROVE
Start date: December 9, 2019
Phase: N/A
Study type: Interventional

The main objective is to determine the performance of the simple eLIFT blood test for advanced liver fibrosis screening in NAFLD and/or alcoholic patients in primary care.

NCT ID: NCT03812146 Completed - Clinical trials for Stress Disorders, Post-Traumatic

Primary Care Treatment Integrating Motivation and Exposure

PC-TIME
Start date: March 1, 2019
Phase: N/A
Study type: Interventional

This project aims to develop and test an integrated brief intervention to reduce heavy alcohol use and PTSD severity in veterans receiving Veterans Affairs Primary Care. Standard brief alcohol interventions have been unsuccessful in reducing heavy drinking in traumatized individuals and current integrated treatment for alcohol use disorder and PTSD are too long to be delivered in Primary Care. Therefore, this application addresses this gap by developing an intervention tailored to the specific needs of heavy drinking veterans who have co- occurring PTSD. This study aims to incorporate two evidenced-based interventions: Brief Motivational Interviewing (BMI) with Prolonged Exposure for Primary Care (PE-PC). This newly developed brief intervention will be piloted in an open trial to gather veteran participant feedback and develop clinician training and fidelity procedures.

NCT ID: NCT03536546 Completed - Drinking, Alcohol Clinical Trials

Improving Outcomes for Emergency Department Patients With Alcohol Problems

Project GOAL
Start date: June 10, 2019
Phase: N/A
Study type: Interventional

The investigators will conduct a study to examine the impact of an alcohol peer-mentor intervention starting in the emergency department (ED) combined with 6 peer booster sessions to reduce hazardous drinking and facilitate primary/specialty care use compared to enhanced usual care. Approximately 450 Veterans with hazardous drinking behaviors will be randomized to one of these two conditions. Follow-up assessments will occur at 3-, 6-, and 12-month post-randomization.

NCT ID: NCT03529409 Completed - Clinical trials for Human Immunodeficiency Virus

Effectiveness & Implementation of a Behavioral Intervention for Adherence and Substance Use in HIV Care in South Africa

Start date: July 30, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to test the effectiveness and implementation of a brief, integrated behavioral intervention for HIV medication adherence and substance use in the HIV care setting in South Africa. The intervention is specifically designed to be implemented by non-specialist counselors using a task sharing model in local HIV clinics. The behavioral intervention will be compared to usual care, enhanced with referral to a local outpatient substance use treatment program (Enhanced Standard of Care - ESOC) on study endpoints (as described in study endpoint section below).

NCT ID: NCT03521115 Completed - Alcohol Drinking Clinical Trials

Family Based Prevention of Alcohol and Risky Sex for Older Teens

Start date: April 1, 2013
Phase: N/A
Study type: Interventional

An online, interactive web-based program for older teens and their parents is designed to address teen alcohol use and teen relationships. The parent-teen dyad both participate in the web-based program and engage in off-line discussion activities. This intervention promotes communication skills, refusal skills, and helps teens consider how to make healthy choices. A total of 411 family dyads (one parent, one teen) were recruited.

NCT ID: NCT03506516 Completed - Clinical trials for Alcohol-Related Disorders

Does Mixing Alcoholic Drinks Make Hangover Worse?

Start date: May 20, 2016
Phase: N/A
Study type: Interventional

Does mixing alcohol make hangover worse?

NCT ID: NCT03497442 Completed - Clinical trials for Alcohol-Related Disorders

Treatment of Asian Flushing Syndrome With Topical Alpha Agonists

Start date: July 12, 2018
Phase: Early Phase 1
Study type: Interventional

Asian Flushing Syndrome (AFS) is a genetic disease affecting approximately 70% of patients of East Asian descent characterized by severe flushing with minimal ethanol consumption. This reaction is cosmetically unattractive and socially limiting. Many Asian patients avoid drinking alcohol on dates, at weddings, and during business events because of this reaction and the perception of being drunk or alcoholic. Ethanol is normally metabolized to acetic acid by two enzymes. The first enzyme, alcohol dehydrogenase (ADH) converts ethanol to acetaldehyde. The second enzyme, aldehyde dehydrogenase 2 (ALDH2) converts the toxic acetaldehyde to harmless acetic acid. When ADH function is increased or ALDH2 function is decreased, the toxic intermediate acetaldehyde accumulates resulting in cutaneous flushing. Over 70% of East Asians have genetic polymorphisms in either ADH or ALDH2 leading to intense flushing with ethanol consumption. There are no effective topical treatments for the Asian Flushing Syndrome. Oral antihistamines have been used with some success in treating symptoms of Asian Flushing Syndrome; however these can have sedating effects and may be dangerous in combination with alcohol. Brimonidine is a selective α2-adrenoceptor agonist that acts through vasoconstriction and is commercially available in a topical gel. This topical treatment is FDA approved for the indication of facial flushing and has a long history of safety in human subjects.

NCT ID: NCT03340051 Completed - Alcohol Dependence Clinical Trials

Remote Alcohol Monitoring and Episodic Thinking

RMET
Start date: September 21, 2017
Phase: N/A
Study type: Interventional

Nearly 18% of United States adults meet criteria for alcohol dependence sometime in their lifetime, with only 24% of those individuals ever receiving any treatment for their disorder (Hasin et al., 2007). The pervasiveness of alcohol dependence indicates a need for continued development of high-impact treatments that are both effective and easily disseminated to a broad population. Recent evidence indicates that Episodic Future Thinking (EFT), the ability to self-project and pre-experience a future event, can help individuals to make changes to habitual behaviors, such as alcohol drinking (Snider et al., 2016). In this study, the investigators will evaluate the efficacy of EFT to help individuals reduce alcohol consumption. The investigators anticipate that EFT will result in a reduction in alcohol consumption over a 2-week experimental period when compared to the control group.

NCT ID: NCT03043443 Completed - Clinical trials for Alcohol-Related Disorders

Melatonin Use for Sleep Problems in Alcohol Dependent Patients

Start date: January 25, 2017
Phase: Phase 2
Study type: Interventional

A double blind Randomized Controlled Trial with two arms will be used. Subjects with Alcohol use disorder and sleep problems will be recruited and assigned randomly to the active treatment Melatonin or Placebo arms. All subjects will be assessed at baseline for demographics. Sleeping problems will be the primary outcome of the study, and it will be measured by the Pittsburgh sleep quality index (PSQI) scale.

NCT ID: NCT02968186 Completed - Clinical trials for Alcohol-Related Disorders

Implementing Screening and Brief Interventions for Excessive Drinkers in Primary Health Care

Start date: November 2016
Phase: N/A
Study type: Interventional

The objective of this study is to investigate the efficacy of an implementation program specifically designed to increase alcohol screening and brief intervention rates in primary health care.